3-Methyl-2-hydroxy-N-ethylbenzamid | 55477-58-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-Methyl-2-hydroxy-N-ethylbenzamid
• 英文别名: N-ethyl-2-hydroxy-3-methylbenzamide
• CAS: 55477-58-2
• 化学式: C₁₀H₁₃NO₂
• mdl: MFCD11130752
• 分子量: 179.219
• InChiKey: HXQOINZDWMMGBM-UHFFFAOYSA-N

物化性质

• 沸点：
  309.7±35.0 °C(Predicted)
• 密度：
  1.113±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• LIGANDS OF SH3 DOMAINS
  申请人：Lawrence David S.

  公开号：US20100035823A1

  公开（公告）日：2010-02-11

  Provided are compounds that bind to SH3 domains. Also provided are combinatorial libraries for discovering such compounds. Methods of identifying a compound that binds to an SH3 domain are also provided. Methods of inhibiting an activity of a protein comprising an SH3 domain are additionally provided. Additionally provided are methods of inhibiting the activity of a protein comprising an SH3 domain and methods of treating a mammal having a deleterious condition that is mediated by a protein comprising an SH3 domain. The use of a compound that binds to the SH3 domain of a protein kinase in the manufacture of a medicament for the treatment of a deleterious condition in a mammal that is dependent on a protein kinase for induction or severity are also provided.