2-Fluoro-4-phenylbut-2-en-1-ol | 105153-70-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Fluoro-4-phenylbut-2-en-1-ol
• CAS: 105153-70-6；105153-71-7
• 化学式: C₁₀H₁₁FO
• 分子量: 166.195
• InChiKey: FBAVMYOHHYPJGW-UHFFFAOYSA-N

物化性质

• 沸点：
  160-170 °C(Press: 2 Torr)
• 密度：
  1.095±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Fluoro-4-phenylbut-2-en-1-ol 、 三氯乙腈 在 sodium hydride 作用下， 以 乙醚 、 正己烷 为溶剂， 生成 2,2,2-Trichloro-acetimidic acid (Z)-2-fluoro-4-phenyl-but-2-enyl ester
  参考文献：
  名称：

  Fluorinated allylic alcohols as building blocks

  摘要：

  A theoretical study on the carbocationic reactivity of 2-fluoroallylic alcohols and derivatives explains some experimental findings. An outline is also given of synthetic approaches towards fluoroallylic amines and more complex carbon skeletons starting with fluoroallylic alcohols.

  DOI：

  10.1016/0022-1139(94)00415-c
• 作为产物：
  描述：

  (Z)-3-phenylprop-1-en-1-yl acetate 在 lithium aluminium tetrahydride 作用下， 以 乙醚 、 二乙二醇二甲醚 为溶剂， 生成 2-Fluoro-4-phenylbut-2-en-1-ol
  参考文献：
  名称：

  Stereoselective synthesis of β-fluoroallyl alcohols

  摘要：

  DOI：

  10.1016/s0040-4039(01)91413-3

文献信息

• Inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and VAP-1 mediated adhesion useful for treatment and prevention of diseases
  申请人：Wang Yanjun Eric

  公开号：US20070293548A1

  公开（公告）日：2007-12-20

  Compositions and methods of using compositions for treatment of inflammatory diseases and immune disorders are provided. Allylamino compounds are disclosed which are inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and/or vascular adhesion protein 1 (VAP-1). The compounds have therapeutic utility in suppressing inflammation and inflammatory responses, and in treatment of several disorders, including multiple sclerosis and stroke.

  提供了用于治疗炎症性疾病和免疫紊乱的组合物及使用组合物的方法。公开了一种烯丙胺化合物，它们是半胱氨酸敏感胺氧化酶（SSAO）和/或血管粘附蛋白1（VAP-1）的抑制剂。这些化合物在抑制炎症和炎症反应方面具有治疗效用，并可用于治疗多发性硬化症和中风等多种疾病。
• INHIBITORS OF SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO) AND VAP-1 MEDIATED ADHESION USEFUL FOR TREATMENT AND PREVENTION OF DISEASES
  申请人：WANG Eric Yanjun

  公开号：US20110269811A1

  公开（公告）日：2011-11-03

  Compositions and methods of using compositions for treatment of inflammatory diseases and immune disorders are provided. Allylamino compounds are disclosed which are inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and/or vascular adhesion protein 1 (VAP-1). The compounds have therapeutic utility in suppressing inflammation and inflammatory responses, and in treatment of several disorders, including multiple sclerosis and stroke.

  提供了治疗炎症性疾病和免疫紊乱的组合物和使用组合物的方法。披露了抑制半胱氨酸敏感胺氧化酶（SSAO）和/或血管黏附蛋白1（VAP-1）的丙烯氨基化合物。这些化合物在抑制炎症和炎症反应以及治疗多种疾病，包括多发性硬化和中风方面具有治疗效用。
• [EN] INHIBITORS OF SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO) AND VAP-1 MEDIATED ADHESION USEFUL FOR TREATMENT AND PREVENTION OF DISEASES<br/>[FR] INHIBITEURS D'ADHÉRENCE MÉDIÉE PAR L'AMINE OXYDASE SENSIBLE AUX SEMI-CARBAZIDES (SSAO) ET LA VAP-1 UTILISÉS DANS LE TRAITEMENT ET LA PRÉVENTION DE MALADIES
  申请人：JOLLA PHARMA

  公开号：WO2007120528A2

  公开（公告）日：2007-10-25

  [EN] Compositions and methods of using compositions for treatment of inflammatory diseases and immune disorders are provided. Allylamino compounds are disclosed which are inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and/or vascular adhesion protein 1 (VAP-I). The compounds have therapeutic utility in suppressing inflammation and inflammatory responses, and in treatment of several disorders, including multiple sclerosis and stroke.
  [FR] L'invention concerne des compositions et des méthodes d'utilisation des compositions dans le traitement de maladies inflammatoires et de troubles immuns. L'invention concerne également des composés allylamino qui constituent des inhibiteurs de l'amine oxydase sensible aux semi-carbazides (SSAO) et/ou de la protéine 1 d'adhérence vasculaire (VAP-I). Lesdits composés sont utilisés d'un point de vue thérapeutique dans la suppression de l'inflammation et des réponses inflammatoires, et dans le traitement de divers troubles, y compris la sclérose en plaques et l'accident vasculaire cérébral.
• Stereoselective synthesis of β-fluoroallyl alcohols
  作者：Takeo Taguchi、Tomoyuki Takigawa、Yumiko Tawara、Tsutomu Morikawa、Yoshiro Kobayashi

  DOI：10.1016/s0040-4039(01)91413-3

  日期：1984.1
• Fluorinated allylic alcohols as building blocks
  作者：Thomas Allmendinger、Christoph Angst、Heinrich Karfunkel

  DOI：10.1016/0022-1139(94)00415-c

  日期：1995.6

  A theoretical study on the carbocationic reactivity of 2-fluoroallylic alcohols and derivatives explains some experimental findings. An outline is also given of synthetic approaches towards fluoroallylic amines and more complex carbon skeletons starting with fluoroallylic alcohols.