2-(2,4-dichlorophenyl)-3-methylquinoxaline | 78874-19-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-(2,4-dichlorophenyl)-3-methylquinoxaline
• 英文别名: 2-(2,4-dichloro-phenyl)-3-methyl-quinoxaline；2-Methyl-3-(2,4-dichlor-phenyl)-chinoxalin
• CAS: 78874-19-8
• 化学式: C₁₅H₁₀Cl₂N₂
• 分子量: 289.164
• InChiKey: ARUQUZRAYZBTRV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.91
• 重原子数：
  19.0
• 可旋转键数：
  1.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  25.78
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  胡椒醛 、 2-(2,4-dichlorophenyl)-3-methylquinoxaline 在 乙酸酐 作用下， 生成 2-<3.4-Methylendioxy-styryl>-3-<2.4-dichlor-phenyl>-chinazolin
  参考文献：
  名称：

  Mahajanshetti,C.S.; Siddappa,S., Indian Journal of Chemistry, 1963, vol. 1, p. 541 - 542

  摘要：

  DOI：
• 作为产物：
  描述：

  (E)-4-(2,4-Dichloro-phenyl)-4-oxo-but-2-enoic acid 在 sodium hydroxide 、 双氧水 作用下， 以 甲醇 、 乙醇 、 丙酮 为溶剂， 反应 7.0h， 生成 2-(2,4-dichlorophenyl)-3-methylquinoxaline
  参考文献：
  名称：

  Elkasaby, M. A.; Noureldin, N. A., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1981, vol. 20, # 5, p. 366 - 368

  摘要：

  DOI：

文献信息

• Chemoselective synthesis of quinoxalines and benzimidazoles by silica gel catalysis
  作者：Chunmei Li、Furen Zhang、Zhen Yang、Chenze Qi

  DOI：10.1016/j.tetlet.2014.08.022

  日期：2014.10

  Treatment of nitroolefins and o-phenylenediamine with silica gel catalyst produced quinoxalines mainly in THF, but gave benzimidazoles efficiently in water. Such a solvent-dependent chemoselective reaction has prominent features of affording two cyclized products selectively with the same substrate, short reaction time, operational simplicity, as well as available starting materials and nontoxic catalysts. In addition, the scope and limitations were explored and a plausible reaction mechanism is proposed. (C) 2014 Elsevier Ltd. All rights reserved.
• Cu(II)-catalyzed synthesis of quinoxalines from o-phenylenediamines and nitroolefins
  作者：Yongxin Chen、Kangning Li、Mingming Zhao、Yuanjiao Li、Baohua Chen

  DOI：10.1016/j.tetlet.2012.11.127

  日期：2013.3

  An easy and efficient copper-catalyzed reaction for the synthesis of quinoxalines from o-phenylenediamines and nitroolefins is developed. This reaction could proceed well without additional base and be applied to various available substrates with a one-step synthetic procedure in moderate to good yields. (c) 2012 Elsevier Ltd. All rights reserved.
• ELKASABY, M. A.;NOURELDIN, N. A., INDIAN J. CHEM., 1981, 20, N 5, 366-368
  作者：ELKASABY, M. A.、NOURELDIN, N. A.

  DOI：——

  日期：——