1-(2,2',4"-trifluoro[1,1';4',1"]terphenyl-4-yl)cyclopropanecarboxylic acid | 749269-90-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2,2',4"-trifluoro[1,1';4',1"]terphenyl-4-yl)cyclopropanecarboxylic acid
• 英文别名: CHF 5105；1-(2,2',4''-trifluoro-[1,1':4',1'']-terphenyl-4-yl)-cyclopropanecarboxylic acid；1-[3-Fluoro-4-[2-fluoro-4-(4-fluorophenyl)phenyl]phenyl]cyclopropane-1-carboxylic acid
• CAS: 749269-90-7
• 化学式: C₂₂H₁₅F₃O₂
• 分子量: 368.355
• InChiKey: YCGKFJFVXHGZAZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• 1-PHENYLALKANECARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF COGNITIVE IMPAIRMENT
  申请人：Chiesi Farmaceutici S.p.A.

  公开号：US20130165505A1

  公开（公告）日：2013-06-27

  Administration of certain 1-phenylalkanecarboxylic acid derivatives is useful for improving Cognitive Function; treating Cognitive Impairment, in particular Mild Cognitive Impairment; and preventing and/or reducing the risk of developing Alzheimer's Disease in a cognitively normal subject.
• 1-PHENYLALKANECARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND MULTIPLE SCLEROSIS
  申请人：Chiesi Farmaceutici S.p.A.

  公开号：US20150065567A1

  公开（公告）日：2015-03-05

  Administration of certain 1-phenylalkanecarboxylic acid derivatives is useful for treating, preventing and/or reducing the risk of developing Alzheimer's Disease and multiple sclerosis.
• US7662995B2
  申请人：——

  公开号：US7662995B2

  公开（公告）日：2010-02-16
• US9592210B2
  申请人：——

  公开号：US9592210B2

  公开（公告）日：2017-03-14