4'-[4-(2-Dimethylamino-ethoxy)-2-methyl-6-propyl-pyrimidin-5-ylmethyl]-biphenyl-2-carbonitrile | 141310-39-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4'-[4-(2-Dimethylamino-ethoxy)-2-methyl-6-propyl-pyrimidin-5-ylmethyl]-biphenyl-2-carbonitrile
• 英文别名: 2-[4-[[4-[2-(Dimethylamino)ethoxy]-2-methyl-6-propylpyrimidin-5-yl]methyl]phenyl]benzonitrile
• CAS: 141310-39-6
• 化学式: C₂₆H₃₀N₄O
• 分子量: 414.55
• InChiKey: JHFIXPPHDRVYHM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  31
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  62
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4'-[4-(2-Dimethylamino-ethoxy)-2-methyl-6-propyl-pyrimidin-5-ylmethyl]-biphenyl-2-carbonitrile 在 trimethyltin azide 作用下， 以 甲苯 为溶剂， 反应 30.0h， 生成 N,N-dimethyl-2-[2-methyl-6-propyl-5-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]pyrimidin-4-yl]oxyethanamine
  参考文献：
  名称：

  Synthesis and angiotensin II receptor antagonist activity of C-linked pyrimidine derivatives

  摘要：

  The synthesis and pharmacological activity of nonpeptide angiotensin II (Ang II) receptor antagonists are presented. These 3-N-substituted pyrimidine-4(3H)-one and 4-O,N,S-substituted pyrimidine derivatives represent a series of C-linked biphenyl tetrazole Ang II antagonists. In vitro, they displayed a high affinity for rat adrenal Ang II receptors, several compounds causing more than 60% displacement of [I-125]Sar(1)-Ile(8)-Ang II from the rat adrenal Ang II receptor at 10(-7) M. In vivo, several compounds displayed a high oral antihypertensive activity in renal hypertensive rat with decreases in systolic arterial pressure (SAP) greater than 60 mmHg 10 mg/kg. 2-[2-Methyl-4-oxo-6-n-propyl-5-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]pyrimidin-3-yl]ethanol hydrochloride (compound 17) was compared with Losartan in the renal artery-ligated rat model. It was shown that at 3 mg/kg po, 17 induced a maximal decrease in mean arterial pressure (MAP) of 60.8 mmHg, which was similar to that was observed with Losartan (maximal decrease of 60 mmHg at 3 mg/kg) with a long duration of action (greater than 16 h).

  DOI：

  10.1016/0223-5234(96)88246-8
• 作为产物：
  描述：

  5-<(2'-cyanobiphenyl-4-yl)methyl>-2-methyl-6-n-propylpyrimidin-4(3H)-one 在 sodium hydride 、 三氯氧磷 作用下， 反应 13.25h， 生成 4'-[4-(2-Dimethylamino-ethoxy)-2-methyl-6-propyl-pyrimidin-5-ylmethyl]-biphenyl-2-carbonitrile
  参考文献：
  名称：

  Synthesis and angiotensin II receptor antagonist activity of C-linked pyrimidine derivatives

  摘要：

  The synthesis and pharmacological activity of nonpeptide angiotensin II (Ang II) receptor antagonists are presented. These 3-N-substituted pyrimidine-4(3H)-one and 4-O,N,S-substituted pyrimidine derivatives represent a series of C-linked biphenyl tetrazole Ang II antagonists. In vitro, they displayed a high affinity for rat adrenal Ang II receptors, several compounds causing more than 60% displacement of [I-125]Sar(1)-Ile(8)-Ang II from the rat adrenal Ang II receptor at 10(-7) M. In vivo, several compounds displayed a high oral antihypertensive activity in renal hypertensive rat with decreases in systolic arterial pressure (SAP) greater than 60 mmHg 10 mg/kg. 2-[2-Methyl-4-oxo-6-n-propyl-5-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]pyrimidin-3-yl]ethanol hydrochloride (compound 17) was compared with Losartan in the renal artery-ligated rat model. It was shown that at 3 mg/kg po, 17 induced a maximal decrease in mean arterial pressure (MAP) of 60.8 mmHg, which was similar to that was observed with Losartan (maximal decrease of 60 mmHg at 3 mg/kg) with a long duration of action (greater than 16 h).

  DOI：

  10.1016/0223-5234(96)88246-8