4-Hydroxybutyl 4-formylbenzoate | 1220985-57-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Hydroxybutyl 4-formylbenzoate
• CAS: 1220985-57-8
• 化学式: C₁₂H₁₄O₄
• 分子量: 222.241
• InChiKey: PIIYTVIFKIUEJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  在 四(三苯基膦)钯 1,3,5-trimethylbarbituric acid 作用下， 以 1,4-二氧六环 、 水 为溶剂， 以96%的产率得到4-Hydroxybutyl 4-formylbenzoate
  参考文献：
  名称：

  使用巴比妥酸衍生物对 Pd(0)-催化的烯丙基醚脱保护的显着溶剂效应：在选择性和连续去除烯丙基、甲基烯丙基和异戊二烯醚中的应用

  摘要：

  使用巴比妥酸衍生物在质子极性溶剂（如 MeOH 和 1,4-二恶烷水溶液中）中 Pd(0) 催化的烯丙基醚脱保护在室温下进行，而不会影响多种官能团。反应温度的控制允许烯丙基、甲代烯丙基和异戊二烯醚的选择性和连续裂解。配体对脱保护作用的研究表明，甲醇中反应性的提高是由于加速氧化加成到 Pd(0)。

  DOI：

  10.1055/s-2007-992352

文献信息

• [EN] PRODRUGS OF GAMMA-HYDROXYBUTYRIC ACID, COMPOSITIONS AND USES THEREOF<br/>[FR] PROMÉDICAMENTS À BASE D'ACIDE GAMMA-HYDROXYBUTYRIQUE, COMPOSITIONS ET UTILISATIONS DE CEUX-CI
  申请人：XW LAB INC

  公开号：WO2017049470A1

  公开（公告）日：2017-03-30

  The present application discloses prodrugs of gamma-hydroxybutyric acid as well as compositions and uses thereof.

  本申请公开了γ-羟基丁酸的前药，以及其组合物和用途。
• Foam compositions and uses thereof
  申请人：NIKE, Inc.

  公开号：US11034813B2

  公开（公告）日：2021-06-15

  A variety of foams and foam components are provided, including foam components for articles of footwear and athletic equipment. The articles include a composition having a foam structure, wherein the composition includes a thermoplastic copolyester elastomer comprising: (a) a plurality of first segments, each first segment derived from a dihydroxy-terminated polydiol; (b) a plurality of second segments, each second segment derived from a diol; and (c) a plurality of third segments, each third segment derived from an aromatic dicarboxylic acid. Methods of making the compositions and foams are provided, as well as methods of making an article of footwear including at least one of the foam components. In some aspects, the foams and foam components can be made by extrusion or injection molding to foam the polymeric composition, or extrusion or injection molding to foam the polymeric composition followed by compression molding of the foam.

  提供了各种泡沫和泡沫组件，包括用于鞋类制品和运动器材的泡沫组件。这些制品包括具有泡沫结构的组合物，其中组合物包括热塑性共聚聚酯弹性体，该弹性体包括：(a) 多个第一段，每个第一段衍生自二羟基端基多元醇；(b) 多个第二段，每个第二段衍生自二元醇；以及 (c) 多个第三段，每个第三段衍生自芳香族二羧酸。提供了制造组合物和泡沫的方法，以及制造包括至少一种泡沫成分的鞋类制品的方法。在某些方面，可通过挤压或注射成型使聚合物组合物发泡，或通过挤压或注射成型使聚合物组合物发泡，然后对泡沫进行压缩成型来制造泡沫和泡沫成分。
• Polyethylene glycol/poly(butylene terephthalate) copolymer coated devices including EVEROLIMUS
  申请人：Hossainy Syed Faiyaz

  公开号：US20130087270A1

  公开（公告）日：2013-04-11

  Methods for making coatings on an implantable device such as a drug-eluting stent comprising a polymer and nano or microparticles of a drug in slow-dissolving polymorph, implantable devices produced by the methods and methods of using the coatings are provided.
• Methods of forming coatings with a crystalline or partially crystalline drug for implantable medical devices using supercritical fluid assisted sorption
  申请人：ADVANCED CARDIOVASCULAR SYSTEMS, INC

  公开号：US20130149430A1

  公开（公告）日：2013-06-13

  Methods for making coatings on an implantable device such as a drug-eluting stent comprising a polymer and nano or microparticles of a drug in slow-dissolving polymorph, implantable devices produced by the methods and methods of using the coatings are provided.
• Methods of Forming Coatings with a Crystalline or Partially Crystalline Drug for Implantable Medical Devices
  申请人：Advanced Cardiovascular Systems, Inc.

  公开号：US20130149431A1

  公开（公告）日：2013-06-13

  Methods for making coatings on an implantable device such as a drug-eluting stent comprising a polymer and nano or microparticles of a drug in slow-dissolving polymorph, implantable devices produced by the methods and methods of using the coatings are provided.