5-(4-methylphenyl)-3-[(2-pyridylamino)methyl]-2,3-dihydro-1,3,4-oxadiazole-2-thione | 132364-79-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-(4-methylphenyl)-3-[(2-pyridylamino)methyl]-2,3-dihydro-1,3,4-oxadiazole-2-thione
• 英文别名: 5-(4-Methylphenyl)-3-[(pyridin-2-ylamino)methyl]-1,3,4-oxadiazole-2-thione
• CAS: 132364-79-5
• 化学式: C₁₅H₁₄N₄OS
• 分子量: 298.368
• InChiKey: HWDCUQMYVXKWEP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  81.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-氨基吡啶 、 5-(4-甲基苯基)-1,3,4-噁二唑-2-硫醇 在 聚合甲醛 作用下， 以 乙醇 为溶剂， 反应 3.0h， 生成 5-(4-methylphenyl)-3-[(2-pyridylamino)methyl]-2,3-dihydro-1,3,4-oxadiazole-2-thione
  参考文献：
  名称：

  Synthesis of some novel 3,5-disubstituted 1,3,4-oxadiazole derivatives and anticancer activity on EAC animal model

  摘要：

  A series of novel 3,5-disubstituted 1,3,4-oxadiazole-2-thione derivatives (1e, 2e, 3e, 4e, and 5e) have been synthesized from different substituted aromatic acids. The structure determination of these compounds have been made on the basis of IR, H-1 NMR, and Elemental analysis. The effect of all the compounds on tumor growth inhibition was evaluated by studying the parameters-tumor volume, percentage of the tumor cell count (viable and nonviable), hematological values, and the mean survival status of the treated animals on eight groups of Swiss albino mice. Compounds were given at the dose of 50 mg/kg body weight intraperitoneally and all exhibited the significant (P < 0.001) anticancer activity compared to control. 5-Fluorouracil was used as a standard drug (20 mg/kg body weight i.p.) in the study. All the compounds demonstrated a prominent anticancer activity. The study supported the derivatives of oxadiazoles for the development as potent anticancer molecules.

  DOI：

  10.1007/s00044-010-9455-6

文献信息

• Srivastava; Srivastava; Pathak, Journal of the Indian Chemical Society, 1990, vol. 67, # 7, p. 606 - 607
  作者：Srivastava、Srivastava、Pathak、Bahel

  DOI：——

  日期：——
• SRIVASTAVA, A.;SRIVASTAVA, SHISHIR K.;PATHAK, R. B.;BAHEL, S. C., J. INDIAN CHEM. SOC., 67,(1990) N, C. 606-607
  作者：SRIVASTAVA, A.、SRIVASTAVA, SHISHIR K.、PATHAK, R. B.、BAHEL, S. C.

  DOI：——

  日期：——
• Synthesis of some novel 3,5-disubstituted 1,3,4-oxadiazole derivatives and anticancer activity on EAC animal model
  作者：Sasmita Dash、B. Ashok Kumar、Jagadish Singh、B. C. Maiti、T. K. Maity

  DOI：10.1007/s00044-010-9455-6

  日期：2011.11

  A series of novel 3,5-disubstituted 1,3,4-oxadiazole-2-thione derivatives (1e, 2e, 3e, 4e, and 5e) have been synthesized from different substituted aromatic acids. The structure determination of these compounds have been made on the basis of IR, H-1 NMR, and Elemental analysis. The effect of all the compounds on tumor growth inhibition was evaluated by studying the parameters-tumor volume, percentage of the tumor cell count (viable and nonviable), hematological values, and the mean survival status of the treated animals on eight groups of Swiss albino mice. Compounds were given at the dose of 50 mg/kg body weight intraperitoneally and all exhibited the significant (P < 0.001) anticancer activity compared to control. 5-Fluorouracil was used as a standard drug (20 mg/kg body weight i.p.) in the study. All the compounds demonstrated a prominent anticancer activity. The study supported the derivatives of oxadiazoles for the development as potent anticancer molecules.