3,5-dimethyl-1-phenylhex-5-en-3-ol | 96694-04-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,5-dimethyl-1-phenylhex-5-en-3-ol
• CAS: 96694-04-1
• 化学式: C₁₄H₂₀O
• 分子量: 204.312
• InChiKey: NCOYJQNDFGTUNK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.34
• 重原子数：
  15.0
• 可旋转键数：
  5.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  20.23
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  3,5-dimethyl-1-phenylhex-5-en-3-ol 在 三乙氧基硅烷 、 C₂₄H₃₄FeNO₅ 、 N-氟代双苯磺酰胺 作用下， 以 乙醇 为溶剂， 反应 3.0h， 以56%的产率得到5-fluoro-3,5-dimethyl-1-phenylhexan-3-ol
  参考文献：
  名称：

  配体促进的铁（III）催化的烯烃氢氟化

  摘要：

  已经开发出铁催化的未活化烯烃的氢氟化反应。事实证明，使用多齿配体和氟化试剂N-氟苯磺酰亚胺（NFSI）对于该反应至关重要，该反应可提供高达94％的产率的各种氟化化合物。

  DOI：

  10.1002/anie.201902607
• 作为产物：
  描述：

  2-methyl-1-(2-methyl-1,3-dithiolan-2-yl)-4-phenylbutan-2-ol 以75%的产率得到
  参考文献：
  名称：

  Wong KenTsung, Yuan Tien-Min, Wang Maw Cherng, Tung HsiaoHsian, Luh Tien-+, J. Amer. Chem. Soc, 116 (1994) N 20, S 8920-8929

  摘要：

  DOI：

文献信息

• Electrochemical allylation of aldehydes and ketones with allylic alcohols
  作者：Jiatai Zhang、Lanlan Zhang、Wei Xie、Meng Chen、Chao Zhang、Yali Qin、Jianyou Zhao、Fan Wang、Zhong-Quan Liu

  DOI：10.1039/d4gc01838a

  日期：——

  electrochemical allylation of unactivated aldehydes and ketones with allylic alcohols. A wide variety of homoallylic alcohols can be obtained by treatment of aldehydes/ketones with allyl alcohols in a simple undivided cell at room temperature. In contrast to previous strategies using allyl organometallic reagents, allylsilicon, allylboron and allyl halides as the allylic precursors, the present method used allyl

  我们在此公开了未活化的醛和酮与烯丙醇的电化学烯丙基化。在室温下，在简单的不可分割的池中用烯丙醇处理醛/酮，可以获得多种高烯丙醇。与之前使用烯丙基有机金属试剂、烯丙基硅、烯丙基硼和烯丙基卤化物作为烯丙基前体的策略相比，本方法使用烯丙醇作为有效的替代物，这使其更加实用和环境可持续。
• Synthesis and Reactions of an Allylic Stannane
  作者：Hiroshi Sano、Makoto Okawara、Yoshio Ueno

  DOI：10.1055/s-1984-31024

  日期：——
• Chelation Assistance in the Activation of Csp3-S Bonds in Nickel-Catalyzed Cross-Coupling Reactions
  作者：Ken-Tsung Wong、Tien-Min Yuan、Maw Cherng Wang、Hsiao-Hsian Tung、Tien-Yau Luh

  DOI：10.1021/ja00099a009

  日期：1994.10

  An unprecedented chelation approach to activate C(sp)3-S bonds in nickel-catalyzed cross-coupling reactions is described. Our theme was based on the formation of a chelation complex which results in the enhancement of the reactivity of aliphatic carbon-sulfur bonds. When two dithioacetal functionalities are located in close proximity, selective olefination of one of these two dithioacetal groups can thus be achieved conveniently. Depending on the relative positions of the newly formed double bond and the remaining dithioacetal group, tandem olefination occurs to give the corresponding 1,5-bis-silyl-substituted pentadienes. Various neighboring heteroatom substituents (OR, OH, NR(2) as well as SR groups) can facilitate the olefination of a dithioacetal group. Poly(thioether) linkage afforded the corresponding degradation products via a B-sulfur elimination process. 1,3-Dimercapto- and 1,3-dithiolatopropanes furnish the cyclopropane formation under nickel-catalyzed reaction conditions. The reaction of a dihydrothiopyran with MeMgI in the presence of the nickel catalyst proceeds via a sulfur-coordinated ir-allyl complex, which can further activate the CS bond to give vinylcyclopropane.
• SANO, HIROSHI;OKAWARA, MAKOTO;UENO, YOSHIO, SYNTHESIS, BRD, 1984, N 11, 933-935
  作者：SANO, HIROSHI、OKAWARA, MAKOTO、UENO, YOSHIO

  DOI：——

  日期：——