3-amino-5-oxo-4,5-dihydropyrazine-2-carboxylic acid [3-((R)-6-amino-2-difluoromethyl-2,3,4,5-tetrahydropyrazin-2-yl)-4-fluorophenyl]amide | 1313525-56-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-amino-5-oxo-4,5-dihydropyrazine-2-carboxylic acid [3-((R)-6-amino-2-difluoromethyl-2,3,4,5-tetrahydropyrazin-2-yl)-4-fluorophenyl]amide
• 英文别名: 2-amino-N-[3-[(3R)-5-amino-3-(difluoromethyl)-2,6-dihydro-1H-pyrazin-3-yl]-4-fluorophenyl]-6-oxo-1H-pyrazine-3-carboxamide
• CAS: 1313525-56-2
• 化学式: C₁₆H₁₆F₃N₇O₂
• 分子量: 395.344
• InChiKey: NWYKTGFANHHXBN-INIZCTEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  147
• 氢给体数：
  5
• 氢受体数：
  9

文献信息

• [EN] PYRAZINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL DISORDERS<br/>[FR] DERIVES DE PYRAZINE ET LEUR UTILISATION DANS LE TRAITEMENT DE TROUBLES NEUROLOGIQUES
  申请人：NOVARTIS AG

  公开号：WO2011080176A1

  公开（公告）日：2011-07-07

  The invention relates to novel heterocyclic compounds of the formula (I) in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their medical use and to medicaments comprising them.

  该发明涉及公式（I）中的新异环化合物，其中所有变量均如规范中定义，以自由形式或盐形式存在，涉及其制备、医疗用途以及包含它们的药物。
• BACE-2 INHIBITORS FOR THE TREATMENT OF METABOLIC DISORDERS
  申请人：NOVARTIS AG

  公开号：US20140128385A1

  公开（公告）日：2014-05-08

  The present invention relates to the use of BACE-2 inhibitors and pharmaceutical compositions comprising BACE-2 inhibitors for treating metabolic disorders related to decreased β cell mass and/or function.

  本发明涉及使用BACE-2抑制剂和含有BACE-2抑制剂的药物组合物治疗与β细胞质量和/或功能下降相关的代谢性疾病。
• PYRAZINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL DISORDERS
  申请人：TINTELNOT-BLOMLEY Marina

  公开号：US20150322038A1

  公开（公告）日：2015-11-12

  The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their medical use and to medicaments comprising them.

  该发明涉及新型杂环化合物，其化学式为：其中所有变量均如规范中定义，以自由形式或盐形式，其制备方法，其医药用途以及包含它们的药物。
• [EN] BACE-2 INHIBITORS FOR THE TREATMENT OF METABOLIC DISORDERS<br/>[FR] INHIBITEURS DE BACE-2 POUR LE TRAITEMENT DE TROUBLES MÉTABOLIQUES
  申请人：NOVARTIS AG

  公开号：WO2012095521A1

  公开（公告）日：2012-07-19

  The present invention relates to the use of BACE-2 inhibitors and pharmaceutical compositions comprising BACE-2 inhibitors for treating metabolic disorders related to decreased β cell mass and/or function.