(4'-iodo-biphenyl-4-yl)-carbamic acid-(3,4-dibromo-hexyl ester) | 95424-12-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4'-iodo-biphenyl-4-yl)-carbamic acid-(3,4-dibromo-hexyl ester)
• 英文别名: (4'-Jod-biphenyl-4-yl)-carbamidsaeure-(3,4-dibrom-hexylester)
• CAS: 95424-12-7
• 化学式: C₁₉H₂₀Br₂INO₂
• 分子量: 581.086
• InChiKey: WNSDMTPBPFVRGN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.83
• 重原子数：
  25.0
• 可旋转键数：
  7.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  38.33
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  反式-3-己烯-1-醇 在 乙醚 、 溴 、 苯 作用下， 生成 (4'-iodo-biphenyl-4-yl)-carbamic acid-(3,4-dibromo-hexyl ester)
  参考文献：
  名称：

  Ketamine anesthesia for pericardial window in a patient with pericardial tamponade and severe COPD

  摘要：

  Purpose: To describe the use and concerns of ketamine anesthesia for pericardial window in a patient with pericardial tamponade and severe chronic obstructive pulmonary disease (COPD) with CO2 retention,Clinical features: A 73-yr-old woman with long-standing COPID and cor pulmonale admitted width pericardial effusion and tamponade had surgery for a pericardial window receiving a total of ketamine 450 mg iv. Arterial pCO(2) increased from 71.8 mmHg preoperatively to 96 mmHg intraoperatively postdrainage of 1000 mL of effusion, Hemodynamic stability and SpO(2) >93% were maintained. Intubation was avoided and concerns of increased pulmonary vascular resistance and potential for right ventricular failure in an already compromised right ventricle were not observed clinically.Conclusion: In this patient with pericardial tamponade, COPD and CO2 retention, the advantages of ketamine included maintaining spontaneous ventilation, avoiding institution and weaning of mechanical ventilation, bronchodilation and relative preservation of the CO2 response curve. Deleterious effects on right ventricular afterload were not observed.

  DOI：

  10.1007/bf03020528