1-(3,4-Dichlorophenyl)-2-methylpropan-1-amine | 17291-95-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(3,4-Dichlorophenyl)-2-methylpropan-1-amine
• CAS: 17291-95-1
• 化学式: C₁₀H₁₃Cl₂N
• mdl: MFCD11641800
• 分子量: 218.12
• InChiKey: GBHNWWAAJIPAFF-UHFFFAOYSA-N

物化性质

• 沸点：
  284.5±25.0 °C(Predicted)
• 密度：
  1.185±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] SERINE/THREONINE KINASE INHIBITORS<br/>[FR] INHIBITEURS DE SÉRINE/THRÉONINE KINASE
  申请人：ARRAY BIOPHARMA INC

  公开号：WO2012118850A1

  公开（公告）日：2012-09-07

  Compounds having the formula I wherein Z, Z1 Z2 Z3, R3a, R3b and Rb and as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.

  具有公式I的化合物，其中Z，Z1，Z2，Z3，R3a，R3b和Rb如本文所定义，是ERK激酶抑制剂。还公开了用于治疗过度增殖性疾病的组合物和方法。
• Amide derivatives as therapeutic agents
  申请人：——

  公开号：US20030171411A1

  公开（公告）日：2003-09-11

  This invention relates to compounds of the general formula 1 which are activators of glucokinase (GK), and which may be useful for the management, treatment, control, or adjunct treatment of diseases or conditions, where increasing glucokinase activity is beneficial, for example diseases such as IGT, Syndrome X, type 2 diabetes, type 1 diabetes, dyslipidemia, hyperlipidemia, hypertension, and obesity.

  本发明涉及一般式1的化合物，其为葡萄糖激酶（GK）的激活剂，可用于管理、治疗、控制或辅助治疗增加葡萄糖激酶活性有益的疾病或病况，例如IGT、综合征X、2型糖尿病、1型糖尿病、脂质代谢异常、高脂血症、高血压和肥胖症。
• N-(alpha-alkylbenzylidene)-alpha-phenylalkylamine, its use and process for producing the same and process for producing intermediate therefor
  申请人：SUMITOMO CHEMICAL COMPANY LIMITED

  公开号：EP0735018A1

  公开（公告）日：1996-10-02

  There is disclosed an N-(α-alkylbenzylidene)-α-phenylalkylamine represented by the general formula (1): wherein R1 represents a lower alkyl group, R2 represents a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group and X represents a halogen atom or a lower alkoxy group, its use and a process for producing the same and processes for producing intermediates therefor.

  本发明公开了通式(1)代表的N-(α-烷基亚苄基)-α-苯基烷基胺： 其中 R1 代表低级烷基，R2 代表氢原子、卤素原子、低级烷基或低级烷氧基，X 代表卤素原子或低级烷氧基。
• Amide derivatives useful as glucokinase activators
  申请人：Novo Nordisk A/S

  公开号：EP2305648A1

  公开（公告）日：2011-04-06

  This invention relates to acetamide derivatives of the general formula (II) which are activators of glucokinase (GK), and which may be useful for the management, treatment, control, or adjunct treatment of diseases or conditions, where increasing glucokinase activity is beneficial, for example diseases such as IGT, Syndrome X, type 2 diabetes, type 1 diabetes, dyslipidemia, hyperlipidemia, hypertension, and obesity.

  本发明涉及通式（II）的乙酰胺衍生物，它们是葡萄糖激酶（GK）的激活剂，可用于控制、治疗、控制或辅助治疗有益于提高葡萄糖激酶活性的疾病或病症，例如 IGT、X 综合征、2 型糖尿病、1 型糖尿病、血脂异常、高脂血症、高血压和肥胖症等疾病。
• SERINE/THREONINE KINASE INHIBITORS
  申请人：Array Biopharma, Inc.

  公开号：EP2681215B1

  公开（公告）日：2015-04-22