紫胶色酸A | 15979-35-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 中文名称: 紫胶色酸A
• 英文名称: Laccaic acid A
• 英文别名: Laccainsaeure A(1)；Laccainsaeure A；7-[5-(2-acetamidoethyl)-2-hydroxyphenyl]-3,5,6,8-tetrahydroxy-9,10-dioxoanthracene-1,2-dicarboxylic acid
• CAS: 15979-35-8
• 化学式: C₂₆H₁₉NO₁₂
• 分子量: 537.436
• InChiKey: IHLWXZNPOVMUFQ-UHFFFAOYSA-N

物化性质

• 碰撞截面：
  218.5 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  39
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  239
• 氢给体数：
  8
• 氢受体数：
  12

文献信息

• AMYLOID-BINDING COMPOUNDS AND METHODS OF USE THEREOF
  申请人：Vanderbilt University

  公开号：US20210011008A1

  公开（公告）日：2021-01-14

  A method of screening for amyloid-binding compounds, amyloid-binding compounds, and a method of detecting amyloid-β (Abeta) plaques in a subject are disclosed. The method of screening for amyloid-binding compounds includes combining amyloid, a dye, and at least one test compound to form a sample solution; equilibrating the sample solution; measuring a fluorescence signal of the sample solution; and comparing the measured fluorescence signal of the sample to a control; wherein attenuation of the fluorescence signal, as compared to the control, indicates that one or more of the test compounds bind amyloid. The amyloid-binding compound includes a compound detected by the screening method. The method of detecting amyloid-β (Abeta) plaques in a subject includes administering one or more of the amyloid-binding compounds to the subject, and detecting the compound within the subject.

  揭示了一种筛选淀粉样结合化合物、淀粉样结合化合物的方法，以及检测受试者中淀粉-β（Abeta）斑块的方法。筛选淀粉样结合化合物的方法包括将淀粉、染料和至少一种试剂化合物组合以形成样品溶液；平衡样品溶液；测量样品溶液的荧光信号；并将所测得的样品的荧光信号与控制进行比较；其中，与控制相比减弱的荧光信号表明一个或多个试剂化合物与淀粉结合。淀粉样结合化合物包括通过筛选方法检测到的化合物。在受试者中检测淀粉-β（Abeta）斑块的方法包括向受试者施用一个或多个淀粉样结合化合物，并在受试者内检测化合物。
• Use of quinones in the treatment of cancer or AIDS
  申请人：RADOPATH LIMITED

  公开号：EP0499467A2

  公开（公告）日：1992-08-19

  The invention relates to a pharmaceutical composition comprising at least one quinone and to its use in the treatment of disease, especially cancer and virus infections. The composition of the invention comprises at least one quinone dissolved or dispersed in a liquid diluent or carrier at a concentration of about 103 moles/litre or below, preferably down to 1018 moles/litre. In the composition the at least one quinone is preferably: An anthraquinone glycoside, more preferably carminic acid. A compound of the formula : wherein R1 is hydrogen, a sugar e.g. -C6H11O5, hydroxy, in which R5 is - CH2NHAc, - CH20H, - CH(NH2)C02H or -CH2NH2; R2 is methyl or -C02H ; R3 is hydrogen, -NH2 or - SO3X in which X is H, Na or K; and R4 is hydrogen or hydroxy. Quinhydrone of the formula : Tetrahydroxyquinone of the formula :

  本发明涉及一种包含至少一种醌的药物组合物及其在治疗疾病，特别是癌症和病毒感染中的用途。 本发明的组合物包含至少一种溶解或分散在液体稀释剂或载体中的醌，浓度约为 103 摩尔/升或更低，最好低至 1018 摩尔/升。 在组合物中，至少一种醌最好是： 蒽醌苷，更优选卡米酸。 式......的化合物： 其中 R1 是氢、糖如-C6H11O5、羟基、 其中 R5 是-CH2NHAc、-CH20H、-CH(NH2)C02H 或-CH2NH2；R2 是甲基或-C02H；R3 是氢、-NH2 或-SO3X，其中 X 是 H、Na 或 K；R4 是氢或羟基。式中的......四氢酮 式中的四羟基醌
• Polymer scale deposition preventive agent
  申请人：SHIN-ETSU CHEMICAL CO., LTD.

  公开号：EP0760378A1

  公开（公告）日：1997-03-05

  A polymer scale deposition preventive agent comprising (a) an aromatic compound having at least eight conjugated π bonds and having a molecular weight of 1,000 or more, and (b) a polyalkylene oxide having a weight-average molecular weight of 2,000 or more, wherein the weight ratio of the component (a) to the component (b) is 100/500 to 100/1, can prevent surely the deposition of polymer scale even in a polymerization system containing a monomer, such as styrene, acrylic acid esters or acrylonitrile, which has a high solvency for a coating film consisting of the conventional polymer scale deposition preventive agent.

  一种聚合物鳞片沉积防止剂，包括(a)至少有八个共轭π键且分子量大于或等于 1,000 的芳香族化合物，以及(b)重量平均分子量大于或等于 2,000 的聚环氧烷，其中组分(a)与组分(b)的重量比为 100/500 至 100/1、即使在含有单体（如苯乙烯、丙烯酸酯或丙烯腈）的聚合体系中，也能有效防止聚合物鳞片的沉积，该单体对由传统聚合物鳞片沉积防止剂组成的涂膜具有很高的溶解度。
• Polymerization process characterized by a two layer coating against scale formation deposited using a steam carrier
  申请人：SHIN-ETSU CHEMICAL CO., LTD.

  公开号：EP0934955A1

  公开（公告）日：1999-08-11

  An improved process for producing a polymer by polymerizing a monomer having an ethylenic double bond in a polymerization vessel having a polymer scale preventive coating film on its inner wall surfaces, etc. is provided. The coating film is formed by coating a first coating liquid containing a compound selected from the group consisting of an aromatic compound having 5 or more conjugated π bonds and a heterocyclic compound having 5 or more conjugated π bonds, and then coating a second coating liquid on the first layer. The first and second coating liquids are applied by means of steam as a carrier. The second layer has a surface having a contact angle to water of less than 60° after its surface has been brought into contact with a solution of mixture of water and a vinyl chloride monomer in a weight ratio of 1:1, at 50°C for 1 hour. This process can shorten the time for forming the coating film to improve productivity, can improve the effect of preventing adhesion of polymer scale, can make colored particles less mix into polymer products obtained by this process, can lessen fish eyes and initial discoloring of formed products and can improve the quality of polymeric products and their formed or molded products.

  本发明提供了一种通过在聚合容器中聚合具有乙烯双键的单体来生产聚合物的改进工艺，该聚合容器的内壁表面等处具有聚合物防垢涂膜。该涂膜是通过涂覆第一涂覆液形成的，第一涂覆液含有选自具有 5 个或更多共轭 π 键的芳香族化合物和具有 5 个或更多共轭 π 键的杂环化合物的一组化合物，然后在第一层上涂覆第二涂覆液。第一种和第二种涂覆液通过蒸汽作为载体进行涂覆。第二层表面与水和氯乙烯单体重量比为 1:1 的混合物溶液在 50°C 下接触 1 小时后，其表面与水的接触角小于 60°。这种工艺可以缩短涂膜的形成时间，从而提高生产率；可以提高防止聚合物鳞片附着的效果；可以使有色颗粒较少地混入通过这种工艺获得的聚合物产品中；可以减少成型产品的鱼眼和初期褪色现象；可以提高聚合物产品及其成型或模塑产品的质量。
• Rust prevention
  申请人：SHIN-ETSU CHEMICAL CO., LTD.

  公开号：EP0957145A2

  公开（公告）日：1999-11-17

  A rust preventive composition including (a) a silicic acid compound and (b) an aromatic amine-based condensation product is provided, which is effective in preventing a Zn-based metallic coating from rusting. Rusting is prevented by forming a coating film containing the components (a) and (b) on the surfaces of the Zn-based metallic coating formed on a base such as a metal plate. The resulting coating film exhibits an excellent corrosion resistance, gives no fear of a health problem such as carcinogenesis and provides a desirable black or blackish appearance to a metal surface. In an embodiment wherein a second coating film containing a silicic acid compound is formed on the first coating film, the corrosion resistance is further improved.

  本发明提供了一种防锈组合物，其中包括(a)硅酸化合物和(b)芳香胺基缩合产物，可有效防止锌基金属涂层生锈。通过在金属板等基底上形成的锌基金属涂层表面上形成一层含有 (a) 和 (b) 组分的涂膜来防止生锈。形成的涂膜具有优异的耐腐蚀性，不会产生致癌等健康问题，并为金属表面提供理想的黑色或微黑色外观。在一个实施方案中，在第一层涂膜上形成了含有硅酸化合物的第二层涂膜，从而进一步提高了耐腐蚀性。