5-chloro-2-(([(4’-fluoro-4-methylbiphenyl-3-yl)amino](oxo)acetyl)amino)benzoic acid sodium salt | 1190221-00-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-chloro-2-(([(4’-fluoro-4-methylbiphenyl-3-yl)amino](oxo)acetyl)amino)benzoic acid sodium salt
• 英文别名: 5-chloro-2-(([(4'-fluoro-4-methylbiphenyl-3-yl)amino](oxo)acetyl)amino)benzoic acid sodium salt；Sodium;5-chloro-2-[[2-[5-(4-fluorophenyl)-2-methylanilino]-2-oxoacetyl]amino]benzoate
• CAS: 1190221-00-1
• 化学式: C₂₂H₁₅ClFN₂O₄*Na
• 分子量: 448.813
• InChiKey: MEPIVNLFDGQTKL-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  98.3
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• INHIBITOR OF PLASMINOGEN ACTIVATOR INHIBITOR-1
  申请人：Renascience CO., LTD.

  公开号：EP2272822A1

  公开（公告）日：2011-01-12

  The present invention relates to a novel compound having plasminogen activator inhibitor-1 (PAI-1) inhibitory activity, and a PAI-1 inhibitor comprising the compound as an active ingredient. The present invention further relates to a pharmaceutical composition that has an inhibitory action on PAI-1 activity and is useful in the prevention and treatment of various diseases whose onset is associated with PAI-1 activity. The novel compound is represented by the following general formula. Each symbol is defined as those in the specification.

  本发明涉及一种具有纤溶酶原激活物抑制剂-1（PAI-1）抑制活性的新型化合物，以及一种包含该化合物作为活性成分的 PAI-1 抑制剂。本发明进一步涉及一种药物组合物，该药物组合物对 PAI-1 活性具有抑制作用，可用于预防和治疗发病与 PAI-1 活性有关的各种疾病。该新型化合物由以下通式表示。 各符号的定义与说明书中的符号相同。
• NOVEL USE FOR PAI-1 INHIBITOR
  申请人：Renascience Co., Ltd.

  公开号：EP2990057A1

  公开（公告）日：2016-03-02

  Provided is a novel use of a plasminogen activator inhibitor-1 inhibitor (PAI-1 inhibitor) that is used as an active ingredient of an agent for controlling a tumor stem cell, an agent for enhancing the antitumor effect of an antitumor agent, an agent for tumor chemotherapy, a stem-cell protecting drug, or a hematopoietic disorder improving agent.

  本发明提供了一种纤溶酶原激活物抑制剂-1 抑制剂（PAI-1 抑制剂）的新用途，该抑制剂可用作控制肿瘤干细胞的药物、增强抗肿瘤药物抗肿瘤效果的药物、肿瘤化疗药物、干细胞保护药物或改善造血障碍药物的活性成分。
• PAI-1 INHIBITOR FOR USE IN ENHANCING THE ANTITUMOR EFFECT OF AN ANTITUMOR AGENT IN A PATIENT
  申请人：Renascience Co., Ltd.

  公开号：EP2990057B1

  公开（公告）日：2019-03-20