9-Ethyl-thioxanthen | 28612-38-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻喃类
• 英文名称: 9-Ethyl-thioxanthen
• 英文别名: 9-ethyl-9H-thioxanthene
• CAS: 28612-38-6
• 化学式: C₁₅H₁₄S
• 分子量: 226.342
• InChiKey: NHXSSWLXPBRIKX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  9-Ethyl-thioxanthen 、 chloroamine-T 以68%的产率得到
  参考文献：
  名称：

  TAMURA Y.; NISHIKAWA Y.; MUKAI C.; SUMOTO K.; IKEDA M.; KISE M., J. ORG. CHEM., 1979, 44, NO 10, 1684-1690

  摘要：

  DOI：
• 作为产物：
  描述：

  phenyl 2-cyclopropylphenyl sulfide 在 四氟硼酸-二乙醚络合物 作用下， 反应 12.0h， 以92%的产率得到9-Ethyl-thioxanthen
  参考文献：
  名称：

  Shabarov, Yu. S.; Pisanova, E. V.; Saginova, L. G., Journal of Organic Chemistry USSR (English Translation), 1980, vol. 16, # 7, p. 1218 - 1221

  摘要：

  DOI：

文献信息

• Synthesis, stereochemistry, and rearrangement of thioxanthen-10-io-(bismethoxycarbonyl)methanides and their 9-alkyl derivatives
  作者：Yasumitsu Tamura、Chisato Mukai、Noriko Nakajima、Masazumi Ikeda、Masaru Kido

  DOI：10.1039/p19810000212

  日期：——

  Thioxanthen-10-io- and 2,4-dimethylthioxanthen-10-io-(bismethoxycarbonyl)methanides and their 9-alkyl derivatives were synthesised by the reaction of the corresponding thioxanthens with bismethoxycarbonylcarbene generated thermally from dimethyl diazomalonate in the presence of copper(II) sulphate. The stereochemistry of the ylides was determined by examination of the n.m.r. spectra and by X-ray analysis

  噻吨-10- IO-和2,4- dimethylthioxanthen -10- IO-（bismethoxycarbonyl）methanides及其9-烷基衍生物通过用从在铜的存在下二甲基diazomalonate热产生bismethoxycarbonylcarbene相应thioxanthens的反应合成（II）硫酸盐。通过检查核磁共振谱和通过反式的X射线分析确定叶立德的立体化学-9-乙基-2,4-二甲基噻吨黄-10--10-（双甲氧基羰基）甲烷。在存在1,8-二氮杂双环[5.4.0]十一碳-7-烯（DBU）的情况下，将甲苯磺酸flu回流在甲苯中会导致重排成相应的9-（双甲氧基羰基甲基）噻吨，但9-异丙基衍生物除外。即使在回流的二甲苯中也很稳定。讨论了重排的机制。
• SHABAROV YU. S.; PISANOVA E. V.; SAGINOVA L. G., ZH. ORGAN. XIMII, 1980, 16, HO 7, 1418-1421
  作者：SHABAROV YU. S.、 PISANOVA E. V.、 SAGINOVA L. G.

  DOI：——

  日期：——
• TAMURA YASUMITSU; MUKAI CHISATO; NAKAJIMA NORIKO; IKEDA MASAZUMI; KIDO MA+, J. CHEM. SOC. PERKIN TRANS, 1981, PART 1, NO 1, 212-217
  作者：TAMURA YASUMITSU、 MUKAI CHISATO、 NAKAJIMA NORIKO、 IKEDA MASAZUMI、 KIDO MA+

  DOI：——

  日期：——
• Novel Neuroprotective Compounds and Uses Thereof
  申请人：Gozin Michael

  公开号：US20100144868A1

  公开（公告）日：2010-06-10

  Disclosed are novel hybrid compounds having a fullerene core residue, one or more bioavailability enhancing moieties and one or more glutamate receptor ligand residues, whereby the bioavailability enhancing moiety allow the compound to reach an effective concentration in physiological media and pass the blood-brain barrier, as defined in the specification. Also disclosed are pharmaceutical compositions containing these hybrid compounds and uses thereof as antioxidants and/or neuroprotective agents for the treatment of medical conditions associated with oxidative stress and/or neural damage, such as, for example, neurological diseases, disorders and trauma, and hence in the treatment of CNS-associated diseases, disorders and trauma, as well as to uses thereof as antiviral, antibacterial, antiglycemic, antiarrhythmic, antidepressant and antitumor agents.