N-[(2-hydroxy-5-nitrophenyl)methylideneamino]-3,4-dimethoxybenzamide | 394687-28-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: N-[(2-hydroxy-5-nitrophenyl)methylideneamino]-3,4-dimethoxybenzamide
• CAS: 394687-28-6
• 化学式: C₁₆H₁₅N₃O₆
• 分子量: 345.312
• InChiKey: MTGCIDSGUMPLDU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  126
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  3,4-二甲氧基苯酰肼 、 5-硝基水杨醛 在 甲酸 作用下， 以 二甲基亚砜 为溶剂， 生成 N-[(2-hydroxy-5-nitrophenyl)methylideneamino]-3,4-dimethoxybenzamide
  参考文献：
  名称：

  Mechanistic differences between in vitro assays for hydrazone-based small molecule inhibitors of anthrax lethal factor

  摘要：

  A systematically generated series of hydrazones were analyzed as potential inhibitors of anthrax lethal factor. The hydrazones were screened using one UV-based and two fluorescence-based in vitro assays. The study identified several inhibitors with IC50 values in the micromolar range, and importantly, significant differences in the types of inhibition were observed with the different assays. (c) 2006 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.bioorg.2006.07.004

文献信息

• COMPOUNDS, COMPOSITIONS AND TREATMENTS FOR V-ATPase RELATED DISEASES
  申请人：Kartner Norbert

  公开号：US20110189306A1

  公开（公告）日：2011-08-04

  The present invention relates to therapeutic and/or prophylactic uses of hydrazide compounds and to pharmaceutical compositions containing one or more of these compounds as an active component for treating a disease or disorder requiring modulation of vacuolar (H+)-ATPases.