4-[N-(4-benzyl-phenyl)-N-(2-methyl-6-piperidin-1-yl-phenyl)-hydrazinocarbonylmethyl]-5-bromo-2-methoxy-benzoic acid hydrochloride | 1075281-70-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[N-(4-benzyl-phenyl)-N-(2-methyl-6-piperidin-1-yl-phenyl)-hydrazinocarbonylmethyl]-5-bromo-2-methoxy-benzoic acid hydrochloride
• 英文别名: Teslexivir hydrochloride；4-[2-[2-(4-benzylphenyl)-2-(2-methyl-6-piperidin-1-ylphenyl)hydrazinyl]-2-oxoethyl]-5-bromo-2-methoxybenzoic acid;hydrochloride
• CAS: 1075281-70-7
• 化学式: C₃₅H₃₆BrN₃O₄*ClH
• 分子量: 679.053
• InChiKey: PYDPVYMURKJIIO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.88
• 重原子数：
  44
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  82.1
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• METHOD FOR THE SYNTHESIS OF A HYDRAZINE THAT CAN BE USED IN THE TREATMENT OF THE PAPILLOMA VIRUS
  申请人：ANACONDDA PHARMA

  公开号：US20150353517A1

  公开（公告）日：2015-12-10

  The invention relates to a method for producing a hydrazine of general formula (I) and the pharmaceutically acceptable salts thereof from an amine of formula (II), characterised in that said method uses a urea of formula (III) as a synthesis intermediate.

  该发明涉及一种从式（II）的胺制备一般式（I）的肼及其药用可接受盐的方法，其特征在于所述方法使用一种式（III）的尿素作为合成中间体。
• PROCEDE DE SYNTHESE D'UNE HYDRAZINE UTILE DANS LE TRAITEMENT DU VIRUS DU PAPILLOME
  申请人：Anaconda Pharma

  公开号：EP2938595B1

  公开（公告）日：2017-06-14
• PIPERIDINE DERIVATIVES AS HUMAN PAPILLOMA VIRUS INHIBITORS
  申请人：AVIRAGEN THERAPEUTICS, INC.

  公开号：US20170079968A1

  公开（公告）日：2017-03-23

  The present disclosure is directed to antiviral compounds directed against the papilloma virus, to pharmaceutical compositions containing them, to their preparation method and synthesis intermediates, as well as to their use for treating or preventing an infection by the papilloma virus. The present method thus provides an efficient way of treating patients that have lesions associated with an infection by the papilloma virus.
• US9452991B2
  申请人：——

  公开号：US9452991B2

  公开（公告）日：2016-09-27
• US9908858B2
  申请人：——

  公开号：US9908858B2

  公开（公告）日：2018-03-06