2-(4-chlorophenyl)thiazolo[5,4-b]pyridine | 91813-37-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-chlorophenyl)thiazolo[5,4-b]pyridine
• 英文别名: 2-(4-Chlorophenyl)-[1,3]thiazolo[5,4-b]pyridine
• CAS: 91813-37-5
• 化学式: C₁₂H₇ClN₂S
• mdl: MFCD02931240
• 分子量: 246.72
• InChiKey: XGQCPIMVGMWKHD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-(2-chloro-3-pyridinyl)-4-chlorophenylamide 在 劳森试剂 作用下， 以 六甲基磷酰三胺 为溶剂， 反应 2.0h， 以36%的产率得到2-(4-chlorophenyl)thiazolo[5,4-b]pyridine
  参考文献：
  名称：

  Couture, Axel; Grandclaudon, Pierre, Heterocycles, 1984, vol. 22, # 6, p. 1383 - 1385

  摘要：

  DOI：

文献信息

• An efficient desulfitative C–C cross coupling of fused thiazolidine-2-thione with boronic acids and boronic acid pinacol esters: formation of fused thiazoles
  作者：Kandasamy Rajaguru、Arumugam Mariappan、Ramachandran Manjusri、Shanmugam Muthusubramanian、Nattamai Bhuvanesh

  DOI：10.1039/c5ra17827d

  日期：——

  An efficient Pd(0)-catalyzed Cu(I)-mediated desulfitative C–C cross-coupling of benzo-fused thiazolidine-2-thione with boronic acids under neutral Liebeskind–Srogl conditions is described. The desulfitative cross coupling of boronic acid pinacol esters has also been demonstrated with fused thiazolidine-2-thione under basic conditions to afford fused thiazoles with good to excellent yields.

  描述了在中性Liebeskind-Srogl条件下有效的Pd（0）催化的Cu（I）介导的苯并稠合的噻唑烷-2-硫酮与硼酸的铜（I）介导的脱硫C-C交叉偶联。还已经证明在碱性条件下用稠合的噻唑烷-2-硫酮与硼酸频哪醇酯进行脱硫交叉偶联，从而以良好或极好的收率得到稠合的噻唑。
• Ynamide-Mediated Thionoester and Dithioester Syntheses
  作者：Chaochao Yao、Jinhua Yang、Xiaobiao Lu、Shuyu Zhang、Junfeng Zhao

  DOI：10.1021/acs.orglett.0c02402

  日期：2020.8.21

  A novel ynamide-mediated synthesis of thionoesters and dithioesters is described. The selective addition reactions of various monothiocarboxylic acids with ynamide furnish alpha-thioacyloxyenamides, which undergo transesterification with nucleophilic -OH or -SH species to afford thionoesters and dithioesters, respectively. The broad substrate scope, mild reaction conditions, and excellent yields make this method an attractive synthetic approach to thionoesters and dithioesters.
• A Facile, One-Pot Synthesis of 2-Arylthiazolo[5,4-<i>b</i>]pyridines
  作者：Axel Couture、Pierre Grandclaudon

  DOI：10.1055/s-1985-31265

  日期：——
• COUTURE, A.;GRANDCLAUDON, P., HETEROCYCLES, 1984, 22, N 6, 1383-1385
  作者：COUTURE, A.、GRANDCLAUDON, P.

  DOI：——

  日期：——
• COUTURE, A.;GRANDCLAUDON, P., SYNTHESIS, BRD, 1985, N 5, 533-535
  作者：COUTURE, A.、GRANDCLAUDON, P.

  DOI：——

  日期：——