1-[2-(2-tert-Butyl-5-methyl-phenoxy)-ethyl]-piperidine | 95422-89-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[2-(2-tert-Butyl-5-methyl-phenoxy)-ethyl]-piperidine
• 英文别名: 1-[2-(2-Tert-butyl-5-methylphenoxy)ethyl]piperidine
• CAS: 95422-89-2
• 化学式: C₁₈H₂₉NO
• 分子量: 275.434
• InChiKey: NWUADJGOTHLXAW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE
  申请人：CHEN Guoqing

  公开号：US20120065185A1

  公开（公告）日：2012-03-15

  Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like.

  选择的杂环化合物对于预防和治疗疾病，如血管生成介导的疾病是有效的。该发明涵盖了新型化合物、类似物、前药和其药学上可接受的衍生物、药物组合物以及预防和治疗涉及癌症等疾病和其他疾病或病症的方法。
• Substituted alkylamine derivatives and methods of use
  申请人：Amgen Inc.

  公开号：EP1798230A1

  公开（公告）日：2007-06-20

  Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  选定的杂环化合物可有效预防和治疗疾病，如血管生成介导的疾病。本发明包括新型化合物、类似物、原药及其药学上可接受的衍生物、药物组合物以及用于预防和治疗涉及癌症等疾病和其他弊病或病症的方法。本发明还涉及制造此类化合物的工艺以及在此类工艺中有用的中间体。
• SUBSTITUTED AMINE DERIVATIVES AND METHODS OF USE IN THE TREATMENT OF ANGIOGENESIS RELATED DISORDERS
  申请人：AMGEN INC.

  公开号：EP1562933B1

  公开（公告）日：2008-03-19
• US7514564B2
  申请人：——

  公开号：US7514564B2

  公开（公告）日：2009-04-07
• US7687643B2
  申请人：——

  公开号：US7687643B2

  公开（公告）日：2010-03-30