(-)-(R)-3-aminoheptane | 130232-58-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (-)-(R)-3-aminoheptane
• 英文别名: (R)-3-heptylamine；(R)-1-ethyl-pentylamine；(R)-1-Aethyl-pentylamin；1-Aethyl-pentylamin；(3R)-heptan-3-amine
• CAS: 130232-58-5
• 化学式: C₇H₁₇N
• 分子量: 115.219
• InChiKey: SRMHHEPXZLWKOK-SSDOTTSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (-)-(R)-3-aminoheptane 、 2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl isothiocyanate 在 三乙胺 作用下， 以 水 、 乙腈 为溶剂， 反应 0.67h， 生成
  参考文献：
  名称：

  Efficient enzymatic kinetic resolution of 2-heptylamine with a highly active acyl donor

  摘要：

  Novozyme435 facilitated kinetic resolution of 2-heptylamine was here presented. Methyl methoxyacetate was used as acyl donor. A survey of influencing factors including hydrogen bonding effect, solvent effect, steric effect, temperature and the amount of acyl donor were investigated in detail. At the optimum conditions, the enantiomeric separation was successfully obtained within 8 h at 20 degrees C. and gave high conversion and optical purity of (R)-2-heptylamine, 48.9% and over 99% respectively. The immobilized lipase B was found to be suitable for the enantiomeric separation of aliphatic amines with good recyclability. (C) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.catcom.2010.04.015
• 作为产物：
  描述：

  3-庚酮 在 Cb-FDH formate dehydrogenase (variant) from Candida boidinii 、 Ch₁-AmDH chimeric amine dehydrogenase generated through domain shuffling of Bb-PhAmDH variant and L-AmDH variant 、 β-烟酰胺腺嘌呤二核苷酸 、 甲酸铵 作用下， 以 水 为溶剂， 反应 48.0h， 以99%的产率得到
  参考文献：
  名称：

  胺脱氢酶：羰基化合物还原胺化的高效生物催化剂

  摘要：

  胺是生产大量化合物的主要目标，这些化合物在制药、农业化学和大宗化学工业中有应用。然而，不对称合成...

  DOI：

  10.1039/c6gc01987k

文献信息

• Producing optically active amino compounds
  申请人：Kaneka Corporation

  公开号：US20020192786A1

  公开（公告）日：2002-12-19

  To provide a method for preparing optically active compounds, which mainly contain (R)-amino compounds, by microbial enzymes efficiently and inexpensively; a polypeptide having stereoselective transaminase activity which can be suitably used for the above preparation method; and a DNA encoding the polypeptide. A method for preparing an optically active amino compound, characterized in stereoselectively transaminating by acting a transaminase on an amino group acceptor, a ketone compound in the presence of an amino group donor, a primary amine; a DNA comprising a nucleotide sequence encoding a polypeptide having stereoselective transaminase activity; and a polypeptide having stereoselective transaminase activity obtainable from a culture of a microorganism belonging to the genus Arthrobacter.

  提供一种通过微生物酶高效、低成本地制备主要含有(R)-氨基化合物的手段；一种具有立体选择性转氨酶活性的多肽，适用于上述制备方法；以及编码该多肽的DNA。一种制备光学活性氨基化合物的方法，其特征在于，在存在氨基供体——一种初级胺的情况下，通过作用转氨酶对氨基受体进行立体选择性转氨，将酮化合物转化为目标化合物；一种包含编码具有立体选择性转氨酶活性的多肽的核苷酸序列的DNA；以及从属于芽孢杆菌属的微生物培养物中获得的具有立体选择性转氨酶活性的多肽。
• Process for producing optically active amino compounds
  申请人：Kaneka Corporation

  公开号：US20010031487A1

  公开（公告）日：2001-10-18

  The method for preparing an optically active (R)-amino compound characterized by the method comprising stereoselectively carrying out amino group transfer by action of an (R)-form-specific transaminase in the co-presence of a ketone compound (amino acceptor), and an amino compound (amino donor) of a racemic form or an (R)-form, to give an optically active (R)-amino compound. According to the present invention, it is made possible to easily prepare at a high yield the optically active (R)-amino compounds and the like having an aryl group and the like at their 1-position, which have been conventionally difficult to prepare.

  制备光学活性(R)-氨基化合物的方法特征在于，在(R)-型特异性转氨酶的作用下，在酮化合物（氨基受体）和一个外消旋或(R)-型的氨基化合物（氨基供体）的共存下，立体选择性地进行氨基基团转移，从而获得光学活性(R)-氨基化合物。根据本发明，可以轻松高产地制备传统上难以制备的在其1-位置具有芳基等基团的光学活性(R)-氨基化合物等。
• PROCESS FOR PRODUCING OPTICALLY ACTIVE AMINO COMPOUNDS
  申请人：KANEKA CORPORATION

  公开号：EP0857790A1

  公开（公告）日：1998-08-12

  A process for producing optically active (R)-amino compounds which comprises treating an aralkyl alkyl ketone compound (the amino receptor) coexisting with a racemic or (R)-amino compound (the amino donor) with an (R)-specific transaminase produced by a microorganism belonging to the genus Arthrobacter and thus effecting stereoselective transamination. This process makes it possible to facilitate the production in a high yield of optically active (R)-amino compounds, etc., having aryl, etc. at the 1-position which have been difficult to synthesize by the conventional techniques.

  一种生产光学活性(R)-氨基化合物的工艺，包括用一种由节肢动物属微生物产生的(R)特异性转氨酶处理与外消旋或(R)-氨基化合物（氨基供体）共存的芳基烷基酮化合物（氨基受体），从而实现立体选择性转氨作用。通过这种工艺，可以高产率地生产出在 1 位上具有芳基等光学活性的（R）-氨基化合物等，而这些化合物用传统技术很难合成。
• Levene; Rothen; Kuna, Journal of Biological Chemistry, 1937, vol. 120, p. 789
  作者：Levene、Rothen、Kuna

  DOI：——

  日期：——
• DNA encoding a polypeptide having stereoselective transaminase activity, and transformants comprising said DNA
  申请人：KANEKA CORPORATION

  公开号：EP0987332B1

  公开（公告）日：2009-08-19