1'-(3-Chlorophenyl)-1',4'-dihydro-4'-hydroxy-spiro[cyclopentane-1,3'(2'H)-[1,8]-naphthyridin]-2'-one | 113077-49-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1'-(3-Chlorophenyl)-1',4'-dihydro-4'-hydroxy-spiro[cyclopentane-1,3'(2'H)-[1,8]-naphthyridin]-2'-one
• 英文别名: 1-(3-chlorophenyl)-4-hydroxyspiro[4H-1,8-naphthyridine-3,1'-cyclopentane]-2-one
• CAS: 113077-49-9
• 化学式: C₁₈H₁₇ClN₂O₂
• 分子量: 328.798
• InChiKey: QHSURXBRSMACIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  53.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1'-(3-chlorophenyl)-spiro[cyclopentane-1,3'-[1,8]-naphthyridin]-2',4'-(1'H)dione 生成 1'-(3-Chlorophenyl)-1',4'-dihydro-4'-hydroxy-spiro[cyclopentane-1,3'(2'H)-[1,8]-naphthyridin]-2'-one
  参考文献：
  名称：

  SIEGE, MARVIN I.;SMITH, SIDNEY R.

  摘要：

  DOI：

文献信息

• Aryl-substituted naphthyridine and pyridopyrazine derivatives, useful as
  申请人：Schering Corporation

  公开号：US04760073A1

  公开（公告）日：1988-07-26

  Aryl-substituted naphthyridines and pyridopyrazines are disclosed which are useful in treating allergic reactions, inflammation, peptic ulcers and/or hyperproliferative skin disease. Pharmaceutical compositions and methods of treatment employing such compounds are also disclosed.

  本文揭示了取代芳基萘啶和吡啶并吡嗪的化合物，可用于治疗过敏反应、炎症、消化性溃疡和/或过度增生性皮肤病。还揭示了使用这些化合物的药物组合物和治疗方法。
• Aryl-substituted naphthyridine and pyridopyrazine derivatives and their
  申请人：Schering Corporation

  公开号：US05011860A1

  公开（公告）日：1991-04-30

  Aryl-substituted naphthyridines and pyridopyrazines are disclosed which are useful in treating allergic reactions, inflammation, peptic ulcers and/or hyperproliferative skin disease. Pharmaceutical compositions and methods of treatment employing such compounds are also disclosed.

  本发明揭示了取代芳基萘啶和吡啶吡嗪，它们可用于治疗过敏反应、炎症、消化性溃疡和/或过度增生性皮肤病。还揭示了使用这些化合物的制药组合物和治疗方法。
• Aryl-substituted naphthyridine and pyridopyrazine derivatives
  申请人：Schering Corporation

  公开号：US04866061A1

  公开（公告）日：1989-09-12

  Aryl-substituted naphthyridines and pyridopyrazines are disclosed which are useful in treating allergic reactions, inflammation, peptic ulcers and/or hyperproliferative skin disease. Pharmaceutical compositions and methods of treatment employing such compounds are also disclosed.

  本发明揭示了取代芳基萘啶和吡啶吡唑，其在治疗过敏反应、炎症、消化性溃疡和/或过度增生性皮肤病方面有用。还揭示了使用这些化合物的制药组合物和治疗方法。
• Immune suppression method employing arly-substituted naphthyridine and
  申请人：Schering Corporation

  公开号：US04882332A1

  公开（公告）日：1989-11-21

  A method and composition for suppressing the immune response are disclosed which employ an immunosuppressing effective amount of certain aryl-substituted naphthyridines and pyrido-pyrazines.

  公开了一种抑制免疫反应的方法和组合物，其采用一定量的含有芳基取代的萘啶和吡啶-吡嗪的免疫抑制有效成分。
• US4760073A
  申请人：——

  公开号：US4760073A

  公开（公告）日：1988-07-26