4-Methoxy-3-(trifluoromethyl)phenol | 53903-59-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Methoxy-3-(trifluoromethyl)phenol
• CAS: 53903-59-6
• 化学式: C₈H₇F₃O₂
• mdl: MFCD09832303
• 分子量: 192.13
• InChiKey: SSPYTHVQEXWESL-UHFFFAOYSA-N

物化性质

• 熔点：
  45-47°

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] CHROMAN-4-ONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION<br/>[FR] DÉRIVÉS DE CHROMAN-4-ONE POUR LE TRAITEMENT ET LA PROPHYLAXIE D'UNE INFECTION PAR LE VIRUS DE L'HÉPATITE B
  申请人：HOFFMANN LA ROCHE

  公开号：WO2020120642A1

  公开（公告）日：2020-06-18

  The present invention provides compounds having the general formula (I) wherein R1 to R10, Gi, G2, X and m are as described herein, compositions including the compounds and methods of using the compounds for treating hepatitis B.

  本发明提供具有一般式（I）的化合物，其中R1至R10、Gi、G2、X和m如本文所述，包括这些化合物的组合物以及使用这些化合物治疗乙型肝炎的方法。
• TRIAZINE COMPOUNDS AND PHARMACEUTICAL USE THEREOF
  申请人：Japan Tobacco Inc.

  公开号：US20150266834A1

  公开（公告）日：2015-09-24

  Provided is a compound having an mPGES-1 inhibitory activity and useful for the prophylaxis or treatment of pain, rheumatism, osteoarthritis, fever, Alzheimer's disease, multiple sclerosis, arteriosclerosis, glaucoma, ocular hypertension, ischemic retinal disease, systemic scleroderma and cancer including colorectal cancer. A compound represented by the formula [I] or a pharmaceutically acceptable salt thereof: wherein each symbol is as defined in the SPECIFICATION.

  提供一种具有mPGES-1抑制活性的化合物，可用于预防或治疗疼痛、风湿病、骨关节炎、发热、阿尔茨海默病、多发性硬化症、动脉硬化、青光眼、眼压增高、缺血性视网膜疾病、全身性硬皮病和包括结肠癌在内的癌症。该化合物由式[I]表示，或其药用可接受的盐：其中每个符号如规范中定义。
• PROCESS FOR THE PREPARATION OF TRIAZINE DERIVATIVES
  申请人：Japan Tobacco Inc.

  公开号：EP3456713A1

  公开（公告）日：2019-03-20

  Provided is a process for the production of a compound represented by the formula [I] or a pharmaceutically acceptable salt thereof: wherein each symbol is as defined in the specification. Said compound has an mPGES-1 inhibitory activity and is useful for the prophylaxis or treatment of pain, rheumatism, osteoarthritis, fever, Alzheimer's disease, multiple sclerosis, arteriosclerosis, glaucoma, ocular hypertension, ischemic retinal disease, systemic scleroderma and cancer including colorectal cancer.

  本发明提供了一种生产式 [I] 所代表的化合物或其药学上可接受的盐的工艺： 其中各符号如说明书中所定义。所述化合物具有 mPGES-1 抑制活性，可用于预防或治疗疼痛、风湿病、骨关节炎、发热、老年痴呆症、多发性硬化症、动脉硬化、青光眼、眼压过高、缺血性视网膜疾病、系统性硬皮病和癌症（包括结直肠癌）。
• POLYURETHANE, POLYURETHANE PRODUCTION METHOD, CONDUCTIVE PASTE COMPOSITION, CONDUCTIVE WIRE, AND METHOD FOR PRODUCING CONDUCTIVE WIRE
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：EP4001336A1

  公开（公告）日：2022-05-25

  A polyurethane contains a weakly acidic functional group having a pKa of 5 to 11. Thus, the present invention provides: a conductive paste composition for forming a stretchable conductive wire which varies slightly in electric conductivity at the time of elongation and shrinkage; and a polyurethane for providing the composition.

  聚氨酯含有 pKa 值为 5 至 11 的弱酸性官能团。因此，本发明提供了：一种用于形成可拉伸导电线的导电浆料组合物，该导电浆料组合物在拉伸和收缩时导电率略有不同；以及一种用于提供该组合物的聚氨酯。
• CHROMAN-4-ONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
  申请人：F. Hoffmann-La Roche AG

  公开号：EP3894004A1

  公开（公告）日：2021-10-20