| 1351224-46-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• CAS: 1351224-46-8
• 化学式: C₂₆H₂₇NO
• 分子量: 369.506
• InChiKey: COYBCIKZHJJXGG-RUZDIDTESA-N

反应信息

• 作为产物：
  描述：

  2-Ethyl-2-methyl-4,4-diphenylpyrrolidine 、 苯甲酰氯 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 [(2S)-2-ethyl-2-methyl-4,4-diphenylpyrrolidin-1-yl]-phenylmethanone 、
  参考文献：
  名称：

  Catalytic, Enantioselective Intramolecular Hydroamination of Primary Amines Tethered to Di- and Trisubstituted Alkenes

  摘要：

  The in situ preparation of chiral amido alkyl ate yttrium complexes from an array of chiral N-benzyl-like-substituted binaphthyldiamines is reported. These chiral heteroleptic complexes are shown to be efficient catalysts for the enantioselective intramolecular hydroamination of primary amines tethered to sterically demanding alkenes at high reaction temperatures. Fine tuning of their chiral environment allowed up to 77% ee to be reached for the cyclization of aminoalkenes bearing 1,2-dialkyl-substituted carbon-carbon double bonds. These chiral complexes also demonstrate the ability to promote the cyclization of amine-tethered trisubstituted alkenes in up to 55% ee, as the first report of the formation of enantioenriched quaternary centers by an hydroamination reaction.

  DOI：

  10.1021/jo202009q