2-(1-imidazolyl)-2',4',6'-trimethylbenzophenone | 122628-40-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(1-imidazolyl)-2',4',6'-trimethylbenzophenone
• 英文别名: (2-Imidazol-1-ylphenyl)-(2,4,6-trimethylphenyl)methanone
• CAS: 122628-40-4
• 化学式: C₁₉H₁₈N₂O
• 分子量: 290.365
• InChiKey: RDPNKKOSDZENLN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  34.9
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• MAG EXPRESSION PROMOTERS
  申请人：Mitsubishi Pharma Corporation

  公开号：EP1186296A1

  公开（公告）日：2002-03-13

  The MAG expression promoter of the present invention contains a compound of the formula (I) wherein each symbol is as defined in the specification, an optically active form thereof or a pharmaceutically acceptable salt thereof. As a compound of the formula (I), 4-[α-hydroxy-5-(1-imidazolyl)-2-methylbenzyl]-3,5-dimethylbenzoic acid is exemplified. The MAG expression promoter of the present invention is useful as an agent for the prophylaxis and/or treatment of a disease of mammals inclusive of human, which mainly presents hypomyelination, further, dysmyelination or demyelination.

  本发明的 MAG 表达启动子含有式（I）化合物 其中各符号如说明书中所定义，是其光学活性形式或其药学上可接受的盐。作为式(I)的化合物，以4-[α-羟基-5-(1-咪唑基)-2-甲基苄基]-3,5-二甲基苯甲酸为例。本发明的 MAG 表达启动子可用作预防和/或治疗哺乳动物（包括人类）疾病的药物，这些疾病主要表现为髓鞘功能减退，进一步表现为髓鞘功能障碍或脱髓鞘。
• MAG expression promoters
  申请人：Kawasaki Masakazu

  公开号：US20050090531A1

  公开（公告）日：2005-04-28

  The MAG expression promoter of the present invention contains a compound of the formula (I) wherein each symbol is as defined in the specification, an optically active form thereof or a pharmaceutically acceptable salt thereof. As a compound of the formula (1), 4-[α-hydroxy-5-(1-imidazolyl)-2-methylbenzyl]-3,5-dimethylbenzoic acid is exemplified. The MAG expression promoter of the present invention is useful as an agent for the prophylaxis and/or treatment of a disease of mammals inclusive of humans, which mainly presents hypomyelination, further, dysmyelination or demyelination.

  本发明的 MAG 表达启动子含有式（I）化合物 其中各符号如说明书中所定义，其光学活性形式或其药学上可接受的盐。作为式（1）的化合物，以 4-[α-羟基-5-(1-咪唑基)-2-甲基苄基]-3,5-二甲基苯甲酸为例。本发明的 MAG 表达启动子可用作预防和/或治疗哺乳动物（包括人类）疾病的药物，这些疾病主要表现为髓鞘功能减退、髓鞘功能障碍或脱髓鞘。
• US7166630B2
  申请人：——

  公开号：US7166630B2

  公开（公告）日：2007-01-23