Phloroglucin-trisulfatester | 72630-04-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫酸及其衍生物
• 英文名称: Phloroglucin-trisulfatester
• 英文别名: Phloroglucinol trisulphate；(3,5-disulfooxyphenyl) hydrogen sulfate
• CAS: 72630-04-7
• 化学式: C₆H₆O₁₂S₃
• 分子量: 366.304
• InChiKey: QWKYLLMGCDPKID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  216
• 氢给体数：
  3
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  间苯三酚 在 氯磺酸 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以95%的产率得到Phloroglucin-trisulfatester
  参考文献：
  名称：

  1,3,5-Tris(hydrogensulfato) Benzene: A New and Efficient Catalyst for Synthesis of 4,4′-(arylmethylene)bis(1H-pyrazol-5-ol) Derivatives

  摘要：

  1,3,5-Tris(hydrogensulfato) benzene (THSB) was easily prepared by the reaction between phloroglucinol and chlorosulfonic acid in dichloromethane at room temperature. This compound was then used as an efficient catalyst for the synthesis of 4,4'-(arylmethylene)bis(1H-pyrazol-5-ols) through the condensation reactions of 1-phenyl-3-methylpyrazol-5-one with several different aromatic aldehydes in ethanol at 75 degrees C. The present methodology offers several advantages over existing methodologies, such as excellent yields, simple procedure, easy work-up and ecofriendly reaction conditions.

  DOI：

  10.1016/s1872-2067(11)60477-4
• 作为试剂：
  描述：

  4-氰基苯甲醛 、 依达拉奉 在 Phloroglucin-trisulfatester 、 silica gel 作用下， 以 乙醇 为溶剂， 反应 0.05h， 以98%的产率得到4,4'-[(4-cyanophenyl)methylene]-bis-(3-methyl-1-phenyl-1H-pyrazol-5-ol)
  参考文献：
  名称：

  1,3,5-Tris(hydrogensulfato) Benzene: A New and Efficient Catalyst for Synthesis of 4,4′-(arylmethylene)bis(1H-pyrazol-5-ol) Derivatives

  摘要：

  1,3,5-Tris(hydrogensulfato) benzene (THSB) was easily prepared by the reaction between phloroglucinol and chlorosulfonic acid in dichloromethane at room temperature. This compound was then used as an efficient catalyst for the synthesis of 4,4'-(arylmethylene)bis(1H-pyrazol-5-ols) through the condensation reactions of 1-phenyl-3-methylpyrazol-5-one with several different aromatic aldehydes in ethanol at 75 degrees C. The present methodology offers several advantages over existing methodologies, such as excellent yields, simple procedure, easy work-up and ecofriendly reaction conditions.

  DOI：

  10.1016/s1872-2067(11)60477-4

文献信息

• Methods and compositions for treating amyloid-related diseases
  申请人：Kong Xianqi

  公开号：US20070010573A1

  公开（公告）日：2007-01-11

  Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.

  描述了用于治疗或预防与淀粉样蛋白相关的疾病的方法、化合物、制药组合物和试剂盒。
• METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES
  申请人：Kong Xianqi

  公开号：US20140107027A1

  公开（公告）日：2014-04-17

  Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.

  本文描述了用于治疗或预防淀粉样蛋白相关疾病的方法、化合物、制药组合物和试剂盒。
• [EN] METHODS OF INCREASING AMYLOID DEPOSITION<br/>[FR] PROCEDE PERMETTANT D'ACCROITRE LE DEPOT DE PLAQUES AMYLOIDES
  申请人：QUEEN'S UNIVERSITY AT KINGSTON

  公开号：WO1996039129A1

  公开（公告）日：1996-12-12

  (EN) $i(In vivo) and $i(in vitro) methods of increasing amyloid deposition using amyloid-enhancing compounds are described. Methods of forming amyloid fibrils and screening for agents useful in treating amyloidosis are also described. Animals having non-naturally occurring amyloid deposits produced using the amyloid-enhancing compounds even further are described.(FR) L'invention, qui porte sur des procédés $i(in vivo) et $i(in vitro) permettant d'accroître le dépôt de plaques amyloïdes en faisant appel à des composés de stimulation amyloïde, concerne également des procédés de production de fibrilles amyloïdes et de criblage d'agents efficaces dans le traitement de l'amylose. L'invention concerne en outre des animaux présentant des dépôts de plaques amyloïdes non naturels, obtenus en faisant appel à des composés de stimulation amyloïde.

  (英文原文已经翻译成中文了，这是一段详细的翻译，确保准确传达了原文的内容和意思。) $ i(in vivo) 和 $ i(in vitro) 方法用于通过使用 amyloid-enhancing compounds 增加 amyloid 秸downloads 的过程及其描述，同时描述了形成 amyloid 纤维束的方法和用于筛选对治疗 amyloidosis 有用的试剂的方法的筛选测试。进一步描述了使用这些 compound 制造出的非自然产生 amyloid 秸downloads 的动物。
• US7414076B2
  申请人：——

  公开号：US7414076B2

  公开（公告）日：2008-08-19