Azd-9684 | 775274-06-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Azd-9684
• 英文别名: (2S,3R)-2-[(6-aminopyridin-3-yl)methyl]-3-sulfanylbutanoic acid
• CAS: 775274-06-1
• 化学式: C₁₀H₁₄N₂O₂S
• 分子量: 226.3
• InChiKey: GYIYAOUGKJSCCG-HTRCEHHLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  77.2
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• [EN] METHOD FOR MONITORING THE PROGRESSION OF FIBRINOLYSIS'646<br/>[FR] PROCÉDÉ DE SUIVI DE LA PROGRESSION DE LA FIBRINOLYSE
  申请人：ASTRAZENECA AB

  公开号：WO2009082340A1

  公开（公告）日：2009-07-02

  It is an object of the present invention to provide biological markers ( 'biomarkers' ) indicative for fibrinolysis. This object has been reached in that a method is provided for monitoring the progression of fibrinolysis in a subject that have received a therapeutically effective dose of a carboxypeptidase U (CPU) inhibitor, comprising detecting and quantifying the amount of protein (s) or polypeptides in a blood sample from said subject. According to another aspect of the invention, a method is provided for monitoring the progression of fibrinolysis in a subject, comprising determining the levels of fibrin fragments, in a blood sample from the subject, wherein said fibrin fragment is selected from the group consisting of the fibrin gamma-chain and fibrin α-fragments.