Pentafluorphenyl-vinyl-aether | 6669-06-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Pentafluorphenyl-vinyl-aether
• 英文别名: 1-Ethenoxy-2,3,4,5,6-pentafluorobenzene
• CAS: 6669-06-3
• 化学式: C₈H₃F₅O
• 分子量: 210.103
• InChiKey: CQOMIYWRLYSFOZ-UHFFFAOYSA-N

物化性质

• 沸点：
  141-142 °C
• 密度：
  1.438±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  五氟苯酚 、 乙酸乙烯酯 、 Acetic acid, mercury(2+) salt (2:1) 、 三氟化硼 以30%的产率得到
  参考文献：
  名称：

  HAYMOBA G. G.; FILIPPOVA A. X.; PIROGOVA G. A.; VYAZANKIN N. S., IZV. AN CCCP. CEP. XIM. 1980, HO 4, 958

  摘要：

  DOI：

文献信息

• Fluorinated thermoplastic elastomers containing polymeric additives and process for preparing such elastomers
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0439734A1

  公开（公告）日：1991-08-07

  New blends of fluorinated thermoplastic elastomers are disclosed that contain a two-phase composition including a continuous phase of a melt processible crystalline thermoplastic fluorocarbon resin and a dispersed phase of an amorphous crosslinked fluoroelastomer, and a dispersion-process-produced, non-fibrillating, non-melt-processible polytetrafluoroethylene (PTFE) powder. The PTFE copolymer is made up of recurring units of hexafluoropropylene, perfluoro(alkyl vinyl ether) wherein the alkyl group has 1-4 carbon atoms, and mixtures thereof. The PTFE compounds uniformly with the two-phase composition without forming visible agglomerates. Poly(phenylene sulfide) powder can be added to the blend to increase melt flow characteristics. Additionally, an uncured fluoroelastomer can be incorporated into the blend to enhance its mechanical properties. The preparation of the fluorinated thermoplastic elastomers involves dynamic curing of the fluoroelastomer in the presence of the molten thermoplastic fluorocarbon resin and the non-melt-processible PTFE resin.

  本发明公开了含氟热塑性弹性体的新型混合物，该混合物含有两相组合物，包括可熔融加工的结晶热塑性氟碳树脂连续相和无定形交联氟弹性体分散相，以及经分散工艺生产的非纤维化、不可熔融加工的聚四氟乙烯（PTFE）粉末。聚四氟乙烯共聚物由六氟丙烯、全氟（烷基乙烯基醚）（其中烷基具有 1-4 个碳原子）及其混合物的重复单元组成。聚四氟乙烯能均匀地与两相组合物混合，不会形成明显的结块。聚苯硫醚粉末可添加到混合物中，以提高熔体流动特性。此外，还可在混合物中加入未固化的氟弹性体，以增强其机械性能。氟化热塑性弹性体的制备包括在熔融热塑性氟碳树脂和不可熔融加工的聚四氟乙烯树脂存在的情况下动态固化氟弹性体。
• CALICHEAMICIN DERATIVES AND ANTIBODY DRUG CONJUGATES THEREOF
  申请人：PFIZER INC.

  公开号：US20190345186A1

  公开（公告）日：2019-11-14

  The present invention is directed to novel calicheamicin derivatives useful as payloads in antibody-drug-conjugates (ADC's), and to payload-linker compounds and ADC compounds comprising the same; to pharmaceutical compositions comprising the same and to methods for using the same to treat pathological conditions such as cancer.
• MUTANT ANTIBODIES AND CONJUGATION THEREOF
  申请人：Pfizer Healthcare Ireland

  公开号：US20210147576A1

  公开（公告）日：2021-05-20

  The present invention relates to a polypeptide comprising 7 β-strands A, B, C, D, E, F, and G sequentially connected together by connecting chains of amino acids, and a first α-helix sequentially located on the EF chain between β-strands E and F, wherein the β-strands are arranged so as to form a first β-sheet comprising β-strands A, B, D, and E, and a second β-sheet comprising β-strands C, F and G, said first and second β-sheets being covalently bonded together so as to form a first Ig domain; wherein the EF chain between β-strands E and F comprises the sequence X 1 -X 2 -X 3 -X 4 -K 5 H 6 (SEQ ID NO:98), and X 1 , X 3 and X 4 are each independently any amino acid residue, characterized in that X 2 is selected from the group consisting of A, G, I, V, L, R, S, T, Q, P, N, M, H, W, and pharmaceutically acceptable salts, stereoisomers, tautomers, solvates, and prodrugs thereof
• US5006594A
  申请人：——

  公开号：US5006594A

  公开（公告）日：1991-04-09
• US8741291B2
  申请人：——

  公开号：US8741291B2

  公开（公告）日：2014-06-03