3-Chloro-2-(1,1-dimethylethyl)-5-fluoropyridine | 1211516-77-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-Chloro-2-(1,1-dimethylethyl)-5-fluoropyridine
• 英文别名: 2-tert-butyl-3-chloro-5-fluoropyridine
• CAS: 1211516-77-6
• 化学式: C₉H₁₁ClFN
• 分子量: 187.64
• InChiKey: QYNYWOZACHODOH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• PYRIDONE COMPOUNDS AND AGRICULTURAL AND HORTICULTURAL FUNGICIDES CONTAINING THE SAME AS ACTIVE INGREDIENTS
  申请人：MITSUI CHEMICALS AGRO, INC.

  公开号：US20200172486A1

  公开（公告）日：2020-06-04

  Provided are a pyridone compound represented by Formula (1): wherein R1 represents a C1-C6 alkyl group which may be substituted, etc., R2 represents a halogen atom, a cyano group, etc., R3 and R4 are independent to each other, and each represents a hydrogen atom, a C1-C6 alkyl group which may be substituted, etc., or in combination with the nitrogen atom to which they are bonded form a pyrrolidinyl group, a piperidinyl group, etc., which may be substituted, Y represents a phenyl group which may be substituted, etc., X represents an oxygen atom or a sulfur atom, and an agricultural and horticultural fungicide containing the same as an active ingredient.

  提供的是由化学式（1）表示的吡啶酮化合物： 其中 R1代表一个可能被取代的C1-C6烷基，等等， R2代表一个卤素原子，一个氰基，等等， R3和R4彼此独立，每个代表一个氢原子，一个可能被取代的C1-C6烷基，等等，或者与它们结合的氮原子形成一个可能被取代的吡咯啉基团，一个哌啶基团，等等， Y代表一个可能被取代的苯基，等等， X代表一个氧原子或硫原子， 以及含有该化合物作为活性成分的农业和园艺用杀菌剂。
• μ-opioid receptor agonist and preparation method therefor and use thereof in field of medicine
  申请人：SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES CO., LTD.

  公开号：US11072601B2

  公开（公告）日：2021-07-27

  Disclosed are a class of μ-opioid receptor agonists and a preparation method therefor and the use thereof in the field of medicine, belonging to the field of medicinal chemistry. The μ-opioid receptor agonists significantly increase the selectivity for a G protein signaling pathway, and not only can exhibit excellent pharmacodynamic effects, but also significantly improve safety.

  本发明公开了一类μ-阿片受体激动剂及其制备方法和在医药领域的应用，属于药物化学领域。该类μ-阿片受体激动剂显著提高了对G蛋白信号通路的选择性，不仅能表现出优异的药效学效应，还能显著提高安全性。
• Pyridone compounds and agricultural and horticultural fungicides containing the same as active ingredients
  申请人：MITSUI CHEMICALS AGRO, INC.

  公开号：US11117863B2

  公开（公告）日：2021-09-14

  Provided are a pyridone compound represented by Formula (1): wherein R1 represents a C1-C6 alkyl group which may be substituted, etc., R2 represents a halogen atom, a cyano group, etc., R3 and R4 are independent to each other, and each represents a hydrogen atom, a C1-C6 alkyl group which may be substituted, etc., or in combination with the nitrogen atom to which they are bonded form a pyrrolidinyl group, a piperidinyl group, etc., which may be substituted, Y represents a phenyl group which may be substituted, etc., X represents an oxygen atom or a sulfur atom, and an agricultural and horticultural fungicide containing the same as an active ingredient.

  本发明提供了一种由式（1）表示的吡啶酮化合物： 其中 R1 代表可被取代的 C1-C6 烷基等 R2 代表卤素原子、氰基等、 R3 和 R4 相互独立，各自代表氢原子、可被取代的 C1-C6 烷基等，或与所键合的氮原子结合形成可被取代的吡咯烷基、哌啶基等、 Y 代表可被取代的苯基等、 X 代表氧原子或硫原子、 以及含有相同活性成分的农用和园艺杀真菌剂。