6-[2'-{[(4-fluorophenyl)-methyl]-oxy}-5'-(trifluoromethyl)-2-biphenylyl]-2-pyrazinecarboxylic acid | 690259-99-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-[2'-{[(4-fluorophenyl)-methyl]-oxy}-5'-(trifluoromethyl)-2-biphenylyl]-2-pyrazinecarboxylic acid
• 英文别名: 6-[2-[2-[(4-fluorophenyl)methoxy]-5-(trifluoromethyl)phenyl]phenyl]pyrazine-2-carboxylic Acid
• CAS: 690259-99-5
• 化学式: C₂₅H₁₆F₄N₂O₃
• 分子量: 468.407
• InChiKey: RRXIMBNEYQOPIH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  72.3
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• [EN] PHENYL COMPOUNDS AND THEIR USE IN THE TREATMENT OF CONDITIONS MEDIATED BY THE ACTION OF PGE2 AT THE EP1 RECEPTOR<br/>[FR] COMPOSES PHENYLIQUES ET LEUR UTILISATION DANS LE TRAITEMENT DE TROUBLES INDUITS PAR L'ACTION DE LA PGE2 AU NIVEAU DU RECEPTEUR EP1
  申请人：GLAXO GROUP LTD

  公开号：WO2005108369A1

  公开（公告）日：2005-11-17

  Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein A, B, Z, R1, R2a, R2b, Rx, R8, and R9 are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine, in particular their use in the treatment of conditions mediated by the action of PGE2 at the EP1 receptor. The EP1 receptor is associated with smooth muscle contraction, pain (in particular inflammatory, neuropathic and visceral), inflammation, allergic activities, renal regulation and gastric or enteric mucus secretion.

  化合物的公式（I）或其药用可接受的衍生物：其中A、B、Z、R1、R2a、R2b、Rx、R8和R9如规范中定义，一种制备这种化合物的方法，包括这种化合物的药物组合物和这种化合物在医学中的用途，特别是它们在通过EP1受体介导的条件治疗中的用途。EP1受体与平滑肌收缩、疼痛（特别是炎症性、神经病理性和内脏疼痛）、炎症、过敏活动、肾脏调节以及胃或肠黏液分泌有关。
• Phenyl Compounds And Their Use In The Treatment Of Conditions Mediated By The Action Of Pge2 At The Ep1 Receptor
  申请人：Bit Antonio Rino

  公开号：US20070225340A1

  公开（公告）日：2007-09-27

  Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein A, B, Z, R 1 , R 2a , R 2b , R x , R 8 , and R 9 are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.

  化合物公式(I)或其药学上可接受的衍生物：其中A、B、Z、R1、R2a、R2b、Rx、R8和R9如规范中所定义，制备这种化合物的过程，包含这种化合物的药物组合物以及在医学上使用这种化合物。
• PHENYL COMPOUNDS AND THEIR USE IN THE TREATMENT OF CONDITIONS MEDIATED BY THE ACTION OF PGE2 AT THE EP1 RECEPTOR
  申请人：GLAXO GROUP LIMITED

  公开号：EP1742916A1

  公开（公告）日：2007-01-17
• US7446222B2
  申请人：——

  公开号：US7446222B2

  公开（公告）日：2008-11-04