(2R,3R,4S,5R)-2-{6-(2,2-Diphenyl-ethylamino)-2-[2-(1-methyl-1H-imidazol-4-yl)-ethylamino]-purin-9-yl}-5-(5-ethyl-[1,2,4]oxadiazol-3-yl)-tetrahydro-furan-3,4-diol | 252761-06-1

• 分子结构分类: 有机化合物 - 苯类化合物
• 英文名称: (2R,3R,4S,5R)-2-{6-(2,2-Diphenyl-ethylamino)-2-[2-(1-methyl-1H-imidazol-4-yl)-ethylamino]-purin-9-yl}-5-(5-ethyl-[1,2,4]oxadiazol-3-yl)-tetrahydro-furan-3,4-diol
• 英文别名: (2R,3R,4S,5R)-2-[6-(2,2-diphenylethylamino)-2-[2-(1-methylimidazol-4-yl)ethylamino]purin-9-yl]-5-(5-ethyl-1,2,4-oxadiazol-3-yl)oxolane-3,4-diol
• CAS: 252761-06-1
• 化学式: C₃₃H₃₆N₁₀O₄
• 分子量: 636.713
• InChiKey: VFTYMVGNRQUSLP-CKXMCULTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  47
• 可旋转键数：
  12
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  174
• 氢给体数：
  4
• 氢受体数：
  12

文献信息

• 2-(PURIN-9-YL)-TETRAHYDROFURAN-3,4-DIOL DERIVATIVES
  申请人：GLAXO GROUP LIMITED

  公开号：EP1090023B1

  公开（公告）日：2003-09-10
• [EN] NEW METHOD OF BRONCHODILATORY THERAPY<br/>[FR] NOUVELLE METHODE DE TRAITEMENT BRONCHODILATATEUR
  申请人：GLAXO GROUP LTD

  公开号：WO2002067909A1

  公开（公告）日：2002-09-06

  As a first aspect of the invention we provide a method of inducing bronchodilation in a human patient which comprises administering to that patient an effective amount of a selective A2a receptor agonist.