(2R)-2-[[4-(3,4-Dichlorophenoxy)-1-piperidinyl]methyl]morpholine | 503455-78-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2R)-2-[[4-(3,4-Dichlorophenoxy)-1-piperidinyl]methyl]morpholine
• 英文别名: (2R)-2-[[4-(3,4-dichlorophenoxy)piperidin-1-yl]methyl]morpholine
• CAS: 503455-78-5
• 化学式: C₁₆H₂₂Cl₂N₂O₂
• 分子量: 345.3
• InChiKey: XLGLRROTHAGJOE-CQSZACIVSA-N

物化性质

• 沸点：
  460.4±45.0 °C(Predicted)
• 密度：
  1.241±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  33.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Piperdine derivatives and their use as modulators of chemokine (especially ccr3) activity
  申请人：——

  公开号：US20040242577A1

  公开（公告）日：2004-12-02

  The invention provides a compound of formula (I): T is C(O) or S(O) 2 ; W is CH 2 , (CH 2 ) 2 , CH(CH 3 ), CH(CH 3 )O or cyclopropyl; X is O, CH 2 , C(O), S, S(O), S(O) 2 or NR 3 ; m is 0 or 1 ; R 1 is optionally substituted aryl or optionally substituted heterocyclyl; R 2 is alkyl (optionally substituted by OH), cycloalkyl, optionally substituted aryl or optionally substituted heterocyclyl; that are modulators of chemokine (especially CCR3) activity and are especially useful for treating asthma and/or rhinitis.

  本发明提供一种化合物，其化学式为(I)：其中T为C(O)或S(O)2；W为CH2、( )2、CH(CH3)、CH( )O或环丙基；X为O、 、C(O)、S、S(O)、S(O)2或NR3；m为0或1；R1为可选取代芳基或可选取代杂环基；R2为烷基（可选取代OH）、环烷基、可选取代芳基或可选取代杂环基。该化合物是趋化因子（特别是CCR3）活性的调节剂，特别适用于治疗哮喘和/或鼻炎。
• Piperidine derivatives useful as modulators of chemokine receptor activity
  申请人：Luckhurst Christopher

  公开号：US20050176708A1

  公开（公告）日：2005-08-11

  The present invention provides a compound of formula (I), wherein: Z is (A:) OR (B) and wherein the remaining variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of achemokine (such as CCR3) or H1 mediated disease state,

  本发明提供了一种化合物，其分子式为(I)，其中：Z为(A:)或(B)，其余变量在此定义；提供了制备此类化合物的方法；以及将此类化合物用于治疗趋化因子（如CCR3）或H1介导的疾病状态的用途。
• Medicine for treating cancer
  申请人：Mataki Chikage

  公开号：US20050176764A1

  公开（公告）日：2005-08-11

  Abstract The present invention is directed to a method for treating cancer, a method for inhibiting histone deacetylase, and a method for facilitating gene therapy, comprising administering an effective amount of a cyclic amine compound represented by the following formula (1):(wherein R1, R2, and R3 each independently represent a hydrogen atom, a halogen atom, a hydroxy group, an alkyl group, a halogen-substituted alkyl group, an alkoxy group, an alkylthio group, a carboxyl group, an alkoxycarbonyl group, or an alkanoyl group; W1 and W2, which are identical to or different from each other, represent N or CH; X represents O, NR4, CONR4, or NR4CO; R4 represents a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group, a substituted or unsubstituted aralkyl group, or a substituted or unsubstituted heteroaralkyl group; and l, m, and n each represent a number of 0 or 1), a salt thereof, or a hydrate thereof.208

  本发明涉及一种治疗癌症、抑制组蛋白去乙酰化酶和促进基因治疗的方法，包括给予下式（1）所表示的环状胺化合物的有效量：（其中R1、R2和R3各自独立地表示氢原子、卤素原子、羟基、烷基、卤代烷基、烷氧基、烷硫基、羧基、烷氧羰基或烷酰基；W1和W2相同或不同，表示N或CH；X表示O、NR4、CONR4或NR4CO；R4表示氢原子、烷基、烯基、炔基、取代或未取代芳基、取代或未取代杂环芳基、取代或未取代芳基烷基、取代或未取代杂环芳基烷基；l、m和n各自表示0或1的数字），其盐或水合物。
• Piperidine Derivatives Useful as Modulators of Chemokine Receptor Activity
  申请人：Luckhurst Christopher

  公开号：US20090069325A1

  公开（公告）日：2009-03-12

  The present invention relates to the compounds of formula (I): in which: and the remaining variables are defined herein. The present invention also relates to a process for preparing such compounds and use of such compounds in the treatment of a chemokine (such as CCR3) or H1 mediated disease state.

  本发明涉及化合物的公式（I）：其中：其余变量在此定义。本发明还涉及制备这种化合物的过程以及在治疗趋化因子（如CCR3）或H1介导的疾病状态中使用这种化合物的用途。
• CYCLIC AMINE COMPOUND
  申请人：Kowa Co., Ltd.

  公开号：EP1422219A1

  公开（公告）日：2004-05-26

  A cyclic amine compound represented by the following general formula (1):    wherein, R1, R2 and R3 each independently represent a hydrogen atom, an alkoxy group, etc.; W1 and W2 are the same or different and represent N or CH ; X represents O, NR4, CONR4 or NR4CO ; R4 represents a hydrogen atom, or an alkyl, aryl, heteroaryl, aralkyl, or heteroaralkyl group; and I, m and n each represents a number of 0 or 1, a salt thereof and a hydrate thereof are provided. These compounds have inhibitory effects on both cell adhesion and cell infiltration and are useful as anti-asthmatic agents, anti-allergic agents, anti-rheumatic agents, anti-arteriosclerotic agents, anti-inflammatory agents, anti-Sjogren's syndrome agents or the like.

  由以下通式（1）代表的环胺化合物： 其中 R1、R2 和 R3 各自独立地代表氢原子、烷氧基等； W1 和 W2 相同或不同，代表 N 或 CH； X 代表 O、NR4、CONR4 或 NR4CO； R4 代表氢原子或烷基、芳基、杂芳基、芳烷基或杂烷基；以及 I、m 和 n 各代表 0 或 1、 提供了其盐和其水合物。 这些化合物对细胞粘附和细胞浸润均有抑制作用，可用作抗哮喘药、抗过敏药、抗风湿药、抗动脉硬化药、抗炎药、抗斯约格伦综合征药或类似药物。