platyphylline | 480-78-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• 英文名称: platyphylline
• 英文别名: (1R,4Z,6S,7R,11S,17R)-4-ethylidene-7-hydroxy-6,7-dimethyl-2,9-dioxa-14-azatricyclo[9.5.1.014,17]heptadecane-3,8-dione
• CAS: 480-78-4；20361-76-6；20361-77-7；90364-90-2
• 化学式: C₁₈H₂₇NO₅
• 分子量: 337.416
• InChiKey: BTHCJHQOYFUIMG-BQSAVQNUSA-N

物化性质

• 熔点：
  131-133 °C
• 沸点：
  539.6±50.0 °C(Predicted)
• 密度：
  1.22±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  24
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  76.1
• 氢给体数：
  1
• 氢受体数：
  6

安全信息

• 包装等级：
  III
• 危险类别：
  6.1(b)
• 危险品运输编号：
  UN 1544

文献信息

• PHARMACEUTICAL COMPOSITION FOR THE PROPHYLAXIS AND TREATMENT OF INFECTIOUS AND NON-INFECTIOUS DIARRHOEA
  申请人：Dikovskiy, Aleksander Vladimirovich

  公开号：EP2486943A1

  公开（公告）日：2012-08-15

  A pharmaceutical composition for the prophylaxis and treatment of infectious and non-infectious diarrhoea comprises medical hydrolysed lignin and living cells of the yeast strain Saccharomyces boulardii in the amaound of 109 - 5* 1010 of living yeast cells to 1 gram of hydrolysed lignin. Preferably, the composition is prepared by uniformly mixing a lyophilized powder of living cells, i.e. cells in an anabiotic state, of the yeast strain Saccharomyces boulardii with powdered medical lignin. This drug (pharmaceutical composition) I proposed preferably as a general remedy for diarrhoea occurring during travel, when it is difficult to make a diagnosis and establish the cause of intestinal upset and an effective drug is urgently required, before consultation with a doctor, which will have a sorbing and marked antimicrobial antiviral effect, as well as a normalizing effect on intestinal motor function. Furthermore, the range of diarrhoeal causative agents that can be suppressed is increased, and discrepancies are reduced and treatment times are shortened with respect to other diverse causative agents of bacterial food poisoning.

  一种用于预防和治疗感染性和非感染性腹泻的药物组合物由医用水解木质素和布拉氏酵母菌活细胞组成，其含量约为109-5*1010个活酵母细胞对1克水解木质素。最好是将布拉氏酵母菌活细胞冻干粉末，即处于无生物状态的细胞，与粉末状医用木质素均匀混合，制备组合物。我建议这种药物（药物组合物）最好作为旅行期间发生腹泻的一般治疗方法，因为在这种情况下很难诊断和确定肠道不适的原因，而且在就诊之前迫切需要一种有效的药物，这种药物具有吸附和明显的抗菌抗病毒作用，以及使肠道运动功能正常化的作用。此外，还能增加可抑制的腹泻致病因子的范围，减少与其他各种细菌性食物中毒致病因子的差异，缩短治疗时间。
• Pharmaceutical composition for use in medical and veterinary ophthalmology
  申请人：Mitotech SA

  公开号：EP2823814A1

  公开（公告）日：2015-01-14

  The invention relates to pharmaceutics, medicine, in particular to manufacturing and use of pharmaceutical compositions of medicines (ophthalmic preparations) comprising mitochondria-addressed antioxidant and a set of auxiliary substances providing effective treatment for ophtalmological diseases in humans and animals.

  本发明涉及制药学、医学，特别是包含线粒体抗氧化剂和一系列辅助物质的药物组合物（眼科制剂）的制造和使用，可有效治疗人类和动物的眼科疾病。
• Pre-analysis treatment method for sample containing plurality of components with greatly different concentrations
  申请人：AiSTI SCIENCE CO., Ltd.

  公开号：US10656126B2

  公开（公告）日：2020-05-19

  A pre-analysis treatment method includes: a first retaining step of supplying, to a solid phase, each predetermined amount of the sample and a first solvent, and allowing a component at low concentration to be retained in the solid phase; a first washing step of supplying the first solvent to the solid phase and removing a component at high concentration from the solid phase; a second retaining step of supplying the sample in a smaller amount than the predetermined amount supplied in the first retaining step, and a second solvent to the solid phase, and allowing the component at high concentration to be retained in the solid phase; and an elution step of simultaneously extruding the components retained in the solid phase with an extrusion solvent.

  一种分析前处理方法包括第一保留步骤：向固相提供各预定量的样品和第一溶剂，并允许低浓度成分保留在固相中； 第一洗涤步骤：向固相提供第一溶剂，并从固相中去除高浓度成分；第二保留步骤：向固相中提供小于第一保留步骤中预定量的样品和第二溶剂，并允许高浓度组分保留在固相中；以及洗脱步骤：同时用挤出溶剂挤出保留在固相中的组分。
• PHARMACEUTICAL COMPOSITION FOR USE IN MEDICAL AND VETERINARY OPHTHALMOLOGY
  申请人：Mitotech SA

  公开号：EP2441453B1

  公开（公告）日：2014-11-26
• PHARMACEUTICAL COMPOSITION FOR USE IN THE PROPHYLAXIS AND TREATMENT OF INFECTIOUS AND NON-INFECTIOUS DIARRHOEA
  申请人：Dikovskiy, Aleksander Vladimirovich

  公开号：EP2486943B1

  公开（公告）日：2014-12-31