5,5'-di(1-(trimethylammonio)methyl)-2,2'-dipyridyl | 1036649-22-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5,5'-di(1-(trimethylammonio)methyl)-2,2'-dipyridyl
• 英文别名: Trimethyl-[[6-[5-[(trimethylazaniumyl)methyl]pyridin-2-yl]pyridin-3-yl]methyl]azanium
• CAS: 1036649-22-5
• 化学式: C₁₈H₂₈N₄
• 分子量: 300.447
• InChiKey: JRVKAMYRRFTGBN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  hexafluorophosphate anion 、 cis-[Ru(dppz)2Cl2]2.H2O 、 5,5'-di(1-(trimethylammonio)methyl)-2,2'-dipyridyl 以 乙二醇 为溶剂， 生成 ruthenium(II)bis(dipyrido[3,2-a:2',3'-c]phenazine)bis(5,5'-di(1-(trimethylammonio)methyl)-2,2-dipyridyl) hexafluorophosphate
  参考文献：
  名称：

  Synthesis, crystal structure and DNA-binding studies of a Ru(II) complex containing two main ligands

  摘要：

  A new Ru(II)-polypyridyl complex, [Ru(L)(dppz)(2)](PF6)(4) (L = 5,5'-di(1-(trimethylammonio)methyl)-2,2'-dipyridyl cation: dppz=dipyrido[3,2-a:2',3'-c]phenazine]), has been synthesized and structurally characterized. The binding of this complex with calf thymus DNA (CT-DNA) has been investigated by spectroscopic and viscosity measurement. Results indicate that the complex binds to CT-DNA via an intercalative mode. Moreover, the complex reveals a highly efficient DNA cleavage activity upon irradiation at 365 nm, during which supercoiled pBR322 DNA was converted to nicked DNA. (C) 2008 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.inoche.2008.09.015