1-(2-乙酰氧基-乙基)-4-苯基-咪唑烷-2-酮 | 65329-73-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 中文名称: 1-(2-乙酰氧基-乙基)-4-苯基-咪唑烷-2-酮
• 英文名称: 1-(2-acetoxy-ethyl)-4-phenyl-imidazolidin-2-one
• 英文别名: 1-(2-acetoxyethyl)-4-phenyl-2-imidazolidone；1-(2-Acetoxyethyl)-4-phenyl-2-imidazolidon；2-(2-oxo-4-phenylimidazolidin-1-yl)ethyl acetate
• CAS: 65329-73-9
• 化学式: C₁₃H₁₆N₂O₃
• 分子量: 248.282
• InChiKey: SAUCUHKFBAYUJF-UHFFFAOYSA-N

物化性质

• 沸点：
  423.9±24.0 °C(Predicted)
• 密度：
  1.179±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-(2-Acetoxyethyl)-4-phenyl-4-imidazolin-2-on 生成 1-(2-乙酰氧基-乙基)-4-苯基-咪唑烷-2-酮
  参考文献：
  名称：

  RAGHU, S.;HOFFMANN, A. K.;SINGH, B.

  摘要：

  DOI：

文献信息

• Synthesis of intermediates for tetramisole, levamisole and their
  申请人：American Cyanamid Co.

  公开号：US04310672A1

  公开（公告）日：1982-01-12

  A process for the manufacture of 1-(2-alkoxyethyl)-4-phenyl-4-imidazolin-2-ones, 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidones, 1-(2-alkoxyethyl)-4-phenyl-imidazolidine-2-thiones, certain of the corresponding 1-(2-hydroxyethyl) derivatives and their 3-acylated derivatives, and certain related compounds which are all useful as intermediates in a new process for the manufacture of tetramisole, di-2,3,5,6-tetrahydro-6-phenylimidazo-[2,1-b]thiazole, and its derivatives. The compound tetramisole is useful as an anthelmintic.

  一种制造1-(2-烷氧基乙基)-4-苯基-4-咪唑啉-2-酮，1-(2-烷氧基乙基)-4-苯基-2-咪唑烷酮，1-(2-烷氧基乙基)-4-苯基咪唑啉-2-硫酮，相应的1-(2-羟乙基)衍生物及其3-酰化衍生物的工艺过程，以及某些相关化合物，它们都可作为制造四唑，二-2,3,5,6-四氢-6-苯基咪唑[2,1-b]噻唑及其衍生物的新工艺的中间体。四唑化合物可用作驱虫剂。
• Optically active 1-oxyethyl-4-phenyl-2-imidazolidones
  申请人：American Cyanamid Company

  公开号：US04087611A1

  公开（公告）日：1978-05-02

  A process for the manufacture of 1-(2-alkoxyethyl)-4-phenyl-4-imidazolin-2-ones, 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidones, 1-(2-alkoxyethyl)-4-phenyl-imidazolidine-2-thiones, certain of the corresponding 1-(2-hydroxyethyl) derivatives, and their 3-acylated derivatives, and certain related compounds which are all useful as intermediates in a new process for the manufacture of the anthelmintic levamisole, (-)-2,3,5,6-tetrahydro-6-phenylimidazo-[2,1-b]thiazole, and its derivatives through conventional resolution procedures. The new process also permits the direct manufacture of optically active 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidone and their 3-acylated derivatives, optically active 1-(2-alkoxyethyl)-4-phenylimidazolidine-2-thiones, and levamisole, the levorotatory isomer of tetramisole, using catalytic amounts of a chiral reducing agent, with the elimination of conventional resolution procedures.

  一种制造1-(2-烷氧基乙基)-4-苯基-4-咪唑啉-2-酮、1-(2-烷氧基乙基)-4-苯基-2-咪唑烷酮、1-(2-烷氧基乙基)-4-苯基咪唑啉-2-硫酮、相应的1-(2-羟乙基)衍生物及其3-酰化衍生物和某些相关化合物的工艺，这些中间体在一种新的工艺中非常有用，该工艺通过常规的分辨过程制造驱虫药左旋丙硫咪唑，(-)-2,3,5,6-四氢-6-苯基咪唑[2,1-b]噻唑醇及其衍生物。该新工艺还允许使用手性还原剂的催化量直接制造手性1-(2-烷氧基乙基)-4-苯基-2-咪唑烷酮及其3-酰化衍生物、手性1-(2-烷氧基乙基)-4-苯基咪唑啉-2-硫酮和左旋丙硫咪唑，而无需进行常规的分辨过程。
• Intermediates for synthesis of tetramisole, levamisole and their
  申请人：American Cyanamid Company

  公开号：US04090025A1

  公开（公告）日：1978-05-16

  A process for the manufacture of 1-(2-alkoxyethyl)-4-phenyl-4-imidazolin-2-ones, 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidones, 1-(2-alkoxyethyl)-4-phenyl-imidazolidine-2-thiones, certain of the corresponding 1-(2-hydroxyethyl) derivatives and their 3-acylated derivatives, and certain related compounds which are all useful as intermediates in a new process for the manufacture of tetramisole, dl-2,3,5,6-tetrahydro-6-phenylimidazo-[2,1-b]thiazole, and its derivatives. The compound tetramisole is useful as an anthelmintic.

  一种制备1-(2-烷氧基乙基)-4-苯基-4-咪唑烷-2-酮、1-(2-烷氧基乙基)-4-苯基-2-咪唑烷酮、1-(2-烷氧基乙基)-4-苯基咪唑烷-2-硫酮、相应的1-(2-羟乙基)衍生物及其3-酰化衍生物和某些相关化合物的制备方法，这些化合物在制备四氢咪唑并[2,1-b]噻唑醇、dl-2,3,5,6-四氢-6-苯基咪唑并[2,1-b]噻唑醇及其衍生物的新工艺中均有用作中间体。四氢咪唑并[2,1-b]噻唑醇化合物可用作驱虫药。
• Synthesis of tetramisole, levamisole and their derivatives
  申请人：American Cyanamid Co.

  公开号：US04314066A1

  公开（公告）日：1982-02-02

  A process for the manufacture of 1-(2-alkoxyethyl)-4-phenyl-4-imidazolin-2-ones, 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidones, 1-(2-alkoxyethyl)-4-phenyl-imidazolidine-2-thiones, certain of the corresponding 1-(2-hydroxyethyl) derivatives, and their 3-acylated derivatives, and certain related compounds which are all useful as intermediates in a new process for the manufacture of the anthelmintic levamisole, (-)-2,3,5,6-tetrahydro-6-phenylimidazo-[2,1-b]thiazole, and its derivatives through conventional resolution procedures. The new process also permits the direct manufacture of optically active 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidone and their 3-acylated derivatives, optically active 1-(2-alkoxyethyl)-4-phenylimidazolidine-2-thiones, and levamisole, the levorotatory isomer of tetramisole, using catalytic amounts of a chiral reducing agent, with the elimination of conventional resolution procedures.

  一种制造1-（2-烷氧基乙基）-4-苯基-4-咪唑啉-2-酮，1-（2-烷氧基乙基）-4-苯基-2-咪唑烷酮，1-（2-烷氧基乙基）-4-苯基咪唑啉-2-硫酮，其相应的1-（2-羟乙基）衍生物和它们的3-酰化衍生物，以及某些相关化合物的制造工艺，这些中间体在制造驱虫药左旋咪唑（-）-2,3,5,6-四氢-6-苯基咪唑[2,1-b]噻唑和其衍生物的新工艺中有用，通过传统分辨过程。新工艺还允许使用手性还原剂的催化量直接制造光学活性的1-（2-烷氧基乙基）-4-苯基-2-咪唑烷酮及其3-酰化衍生物，光学活性的1-（2-烷氧基乙基）-4-苯基咪唑啉-2-硫酮和左旋咪唑，即四氢咪唑的左旋异构体，消除了传统的分辨过程。
• US4087611A
  申请人：——

  公开号：US4087611A

  公开（公告）日：1978-05-02