methyl 2-{2-[3'-(acetylamino)-1,1'-biphenyl-4-yl]ethyl}-5-phenylpentanoate | 1232027-00-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 2-{2-[3'-(acetylamino)-1,1'-biphenyl-4-yl]ethyl}-5-phenylpentanoate
• 英文别名: Methyl 2-[2-[4-(3-acetamidophenyl)phenyl]ethyl]-5-phenylpentanoate
• CAS: 1232027-00-7
• 化学式: C₂₈H₃₁NO₃
• 分子量: 429.559
• InChiKey: IAKNRIOJSGIZTN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  32
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] ALKANOIC ACID DERIVATIVES AND THEIR THERAPEUTIC USE AS HDAC INHIBITORS<br/>[FR] DÉRIVÉS DE L'ACIDE ALCANOÏQUE ET LEUR UTILISATION THÉRAPEUTIQUE EN TANT QU'INHIBITEURS DE L'HDAC
  申请人：CRYSTAX PHARMACEUTICALS S L

  公开号：WO2010070076A1

  公开（公告）日：2010-06-24

  The invention related to alkanoic acid derivatives of Formula (IIa) and (IIb). These compounds of the invention were found to have activity as HDAC inhibitors.

  这项发明涉及到公式（IIa）和（IIb）的烷酸衍生物。发明中的这些化合物被发现具有作为HDAC抑制剂的活性。
• [EN] PHARMACEUTICAL PRODUCT COMPRISING A P38 KINASE INHIBITOR AND A SECOND ACTIVE INGREDIENT<br/>[FR] PRODUIT PHARMACEUTIQUE CONTENANT UN INHIBITEUR DE KINASE P38 ET UN SECOND INGRÉDIENT ACTIF
  申请人：ASTRAZENECA AB

  公开号：WO2010071583A1

  公开（公告）日：2010-06-24

  The invention provides a pharmaceutical product, kit or composition comprising a first active ingredient which is N-Cyclopropyl-3-fluoro-4-methyl-5-[3-[[l-[2-[2- (methylamino)ethoxy]phenyl]cyclopropyl]amino]-2-oxo-l(2H)-pyrazinyl]- benzamide or a salt thereof, and a second active ingredient selected from: a non-steroidal Glucocorticoid Receptor (GR Receptor) Agonist; an antioxidant; a β2 adrenoceptor agonist; a CCRl antagonist; a chemokine antagonist (not CCRl); a corticosteroid; a CRTh2 antagonist; a DPI antagonist; an Ηistone Deacetylase activator; an IKK2 kinase inhibitor; a COX inhibitor; a lipoxygenase inhibitor; a leukotriene receptor antagonist; a MABA compound; an MPO inhibitor; a muscarinic antagonist; a PDE4 inhibitor; a PPARγ agonist; a protease inhibitor; a Statin; a thromboxane antagonist; a vasodilator; or, an ENAC blocker (Epithelial Sodium-channel blocker); and its use in the treatment of respiratory disease.