piperidin-1-yl(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)methanone | 1418292-15-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: piperidin-1-yl(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)methanone
• 英文别名: 1-{4-[5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzoyl}piperidine；piperidin-1-yl-[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methanone
• CAS: 1418292-15-5
• 化学式: C₁₅H₁₄F₃N₃O₂
• 分子量: 325.29
• InChiKey: RLVQKWNRZLOFFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  59.2
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• [EN] NOVEL TRIFLUOROMETHYL-OXADIAZOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE<br/>[FR] NOUVEAUX DÉRIVÉS DE TRIFLUOROMÉTHYL-OXADIAZOLE ET LEUR UTILISATION POUR LE TRAITEMENT DE MALADIES
  申请人：NOVARTIS AG

  公开号：WO2013008162A1

  公开（公告）日：2013-01-17

  The invention relates to novel trifluoromethyl-oxadiazole derivatives of formula (I), and pharmaceutically acceptable salts thereof, (I) in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, pharmaceutical combinations thereof, and their use as medicaments, particularly for the treatment of neurodegeneration, muscle atrophy or metabolic syndrome via inhibition of HDAC4.

  该发明涉及新颖的三氟甲基噁嘌呤衍生物的公式(I)，及其在药学上可接受的盐，公式(I)中所有变量如规范中所定义，以及其药用组合物、药物组合物，以及它们作为药物的用途，特别是用于通过抑制HDAC4治疗神经退行性疾病、肌肉萎缩或代谢综合征。
• OXADIAZOLE COMPOUND AND FUNGICIDE FOR AGRICULTURAL AND HORTICULTURAL USE
  申请人：IWATA Jun

  公开号：US20210403461A1

  公开（公告）日：2021-12-30

  This fungicide for agricultural and horticultural use includes a compound represented by formula (I) (in the formula, X represents a halogen group, or the like; n represents any integer of 0 to 4; when n is 2 or more, X may be the same or different; L represents a single bond or a substituted or unsubstituted C1-6 alkylene group; Q is a group represented by formula (Q-1) or formula (Q-2) (in the formulae, * represents a binding site; Y 1 is N or CR 1 ; Y 2 is N or CR 2 ; Y 3 is N or CR 3 ; Y 4 is N or CR 4 , at least two of Y 1 to Y 4 are not nitrogen atoms; R 1 , R 2 , R 3 , and R 4 , each independently represent a hydrogen atom, a substituted or unsubstituted C1-6 alkyl group, or the like; R represents a substituted or unsubstituted C1-6 alkyl group or the like; G represents a substituted or unsubstituted C1-6 alkylene group; T represents a substituted or unsubstituted C1-6 alkylene group; Y 5 is N or CH)) or a salt thereof.

  这种用于农业和园艺的杀菌剂包括一个由公式（I）表示的化合物（在公式中，X表示卤素基团或类似物；n表示0至4的任意整数；当n为2或更多时，X可以相同或不同；L表示单键或取代或未取代的C1-6烷基烯基团；Q是由公式（Q-1）或公式（Q-2）表示的基团（在公式中，*表示结合位；Y1是N或CR1；Y2是N或CR2；Y3是N或CR3；Y4是N或CR4，其中至少两个Y1到Y4不是氮原子；R1、R2、R3和R4分别独立地表示氢原子、取代或未取代的C1-6烷基基团或类似物；R表示取代或未取代的C1-6烷基基团或类似物；G表示取代或未取代的C1-6烷基烯基团；T表示取代或未取代的C1-6烷基烯基团；Y5是N或CH）或其盐。
• NOVEL TRIFLUOROMETHYL-OXADIAZOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE
  申请人：Hebach Christina

  公开号：US20140142105A1

  公开（公告）日：2014-05-22

  The invention relates to novel trifluoromethyl-oxadiazole derivatives of formula (I), and pharmaceutically acceptable salts thereof, (I) in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, pharmaceutical combinations thereof, and their use as medicaments, particularly for the treatment of neurodegeneration, muscle atrophy or metabolic syndrome via inhibition of HDAC4.

  本发明涉及公式（I）的新型三氟甲基-噁二唑衍生物及其药学上可接受的盐，其中所有变量均如规范中定义，其制备的药物组合物、药物组合物以及它们作为药物的用途，特别是通过抑制HDAC4治疗神经退行性、肌肉萎缩或代谢综合症。
• Oxadiazole compound and fungicide for agricultural and horticultural use
  申请人：Nippon Soda Co., Ltd.

  公开号：US11365193B2

  公开（公告）日：2022-06-21

  This fungicide for agricultural and horticultural use includes a compound represented by formula (I) (in the formula, X represents a halogen group, or the like; n represents any integer of 0 to 4; when n is 2 or more, X may be the same or different; L represents a single bond or a substituted or unsubstituted C1-6 alkylene group; Q is a group represented by formula (Q-1) or formula (Q-2) (in the formulae, * represents a binding site; Y1 is N or CR1; Y2 is N or CR2; Y3 is N or CR3; Y4 is N or CR4, at least two of Y1 to Y4 are not nitrogen atoms; R1, R2, R3, and R4, each independently represent a hydrogen atom, a substituted or unsubstituted C1-6 alkyl group, or the like; R represents a substituted or unsubstituted C1-6 alkyl group or the like; G represents a substituted or unsubstituted C1-6 alkylene group; T represents a substituted or unsubstituted C1-6 alkylene group; Y5 is N or CH)) or a salt thereof.

  这种用于农业和园艺的杀真菌剂包括由式(I)代表的化合物（在式中，X代表卤素基团或类似基团；n代表0至4的任意整数；当n为2或更多时，X可以相同或不同；L代表单键或取代或未取代的C1-6亚烷基；Q是由式(Q-1)或式(Q-2)代表的基团（在式中，*代表结合位点；Y1是N或CR1；Y2是N或CR2；Y3是N或CR3；Y4是N或CR4，Y1至Y4中至少有两个不是氮原子；R1、R2、R3和R4各自独立地代表氢原子、取代或未取代的C1-6烷基或类似物；R代表取代或未取代的C1-6烷基或类似物；G代表取代或未取代的C1-6亚烷基；T代表取代或未取代的C1-6亚烷基；Y5是N或CH))或其盐。
• US9056843B2
  申请人：——

  公开号：US9056843B2

  公开（公告）日：2015-06-16