2-(2,5-Dichlorophenyl)oxirane | 2783-27-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2,5-Dichlorophenyl)oxirane
• CAS: 2783-27-9
• 化学式: C₈H₆Cl₂O
• mdl: MFCD09732950
• 分子量: 189.04
• InChiKey: NYBOOEJUTPHCNU-UHFFFAOYSA-N

物化性质

• 沸点：
  241.2±40.0 °C(Predicted)
• 密度：
  1.428±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• PROCESS FOR PRODUCING OPTICALLY ACTIVE (-)-2-HALO-1-(SUBSTITUTED PHENYL)ETHANOL AND (-)-SUBSTITUTED STYRENE OXIDE
  申请人：KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA

  公开号：EP0493617A1

  公开（公告）日：1992-07-08

  A process for producing (-)-substituted styrene oxide efficiently, which comprises reducing 2-bromo-1-(3'-chlorophenyl)ethanone asymmetrically into (-)-2-bromo-1-(3'-chlorophenyl)ethanol in the presence of a microorganism belonging to any of the 11 genera including Ashbya and Brettanomyces, and cyclizing the isolated and purified product under an alkaline condition into (-)-substituted styrene oxide.

  一种高效生产(-)-取代的氧化苯乙烯的工艺，它包括在属于 Ashbya 和 Brettanomyces 等 11 个属中任何一个属的微生物存在下，将 2-溴-1-(3'-氯苯基)乙酮不对称地还原成(-)-2-溴-1-(3'-氯苯基)乙醇，并在碱性条件下将分离和纯化的产物环化成(-)-取代的氧化苯乙烯。
• Processes for production of optically active epoxides
  申请人：DAICEL CHEMICAL INDUSTRIES CO., LTD.

  公开号：EP0611826A2

  公开（公告）日：1994-08-24

  A microorganism or a preparation thereof is permitted to act on a mixture of enantiomers of an epoxide such as 3-chlorostyrene oxide and the product optically active epoxide is recovered. The microorganism able to produce an optically active (S)-epoxide from the mixture of enantiomers of the epoxide include, for example, a microorganism strain belonging to the genus Candida, the genus Rhodosporidium, the genus Rhodococcus and the genus Nosardioides. Examples of the microorganism capable of producing an optically active (R)-epoxide from said mixture include a microorganism strain belonging to the genus Trichosporon, the genus Geotrichum, the genus Corynebacterium, the genus Micrococcus and the genus Brevibacterium. The objective optically active epoxide can efficiently be obtained with ease and simplicity from the corresponding mixture of enantiomers of the epoxide.

  允许微生物或其制剂作用于环氧化物（如 3-氯苯乙烯氧化物）的对映体混合物，并回收光学活性环氧化物产品。能够从环氧化物的对映体混合物中产生光学活性（S）-环氧化物的微生物包括，例如，属于白色念珠菌属、Rhodosporidium 属、Rhodococcus 属和 Nosardioides 属的微生物菌株。能够从所述混合物中产生光学活性（R）-环氧化物的微生物菌株的例子包括属于三孢菌属、革囊菌属、高丽杆菌属、微球菌属和布雷维杆菌属的微生物菌株。从相应的环氧化物对映体混合物中可以高效、简便地获得具有光学活性的环氧化物。
• PROCESS FOR PRODUCING OPTICALLY ACTIVE (-)-2-HALO-1-(SUBSTITUTED PHENYL)ETHANOL
  申请人：KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA

  公开号：EP0493617B1

  公开（公告）日：1999-10-06
• US5266485A
  申请人：——

  公开号：US5266485A

  公开（公告）日：1993-11-30
• US5672504A
  申请人：——

  公开号：US5672504A

  公开（公告）日：1997-09-30