allylphosphonic acid phenyl ester allyl ester | 13067-73-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: allylphosphonic acid phenyl ester allyl ester
• 英文别名: Allylphenyl-allyphosphonat；[Prop-2-enoxy(prop-2-enyl)phosphoryl]oxybenzene
• CAS: 13067-73-7
• 化学式: C₁₂H₁₅O₃P
• 分子量: 238.223
• InChiKey: OLAPKRWGBTWGHH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  allylphosphonic acid phenyl ester allyl ester 在 Grubbs catalyst first generation 作用下， 以 二氯甲烷 为溶剂， 反应 8.0h， 以90%的产率得到2-phenoxy-3,6-dihydro-1,2-oxaphosphinine 2-oxide
  参考文献：
  名称：

  Synthesis of Cyclic Phosphonate Analogues of (Lyso)phosphatidic Acid Using a Ring-Closing Metathesis Reaction

  摘要：

  We describe a versatile and efficient method for the preparation of acyloxy-substituted six-membered cyclic phosphonates using the ring-closing metathesis. After closure, the key cyclic phosphonate intermediate was dihydroxylated and converted to a new class of conformationally constrained PA and LPA analogues. The oleoyloxy-substituted cyclic phosphonate 4 had unique receptor-selective properties as a ligand, showing partial activation of the LPA(2) GPCR and weak antagonism of the LPA(1) GPCR.

  DOI：

  10.1021/jo0607919
• 作为产物：
  描述：

  Phosphorous acid diallyl ester phenyl ester 在 nickel dichloride 作用下， 反应 4.0h， 以82%的产率得到allylphosphonic acid phenyl ester allyl ester
  参考文献：
  名称：

  氯化镍催化烯丙基亚磷酸酯的重排

  摘要：

  在氯化镍的催化下，烯丙基亚磷酸酯可以重排成相应的烯丙基膦酸酯。当烯丙基中间体中的碳金属键的β位上有氢原子时，通过消除反应形成二烯和膦酸二烷基酯。讨论了这些反应的机理。

  DOI：

  10.1016/s0022-328x(00)99689-x

文献信息

• ASYMMETRIC ORGANIC PEROXIDE, CROSSLINKING AGENT COMPRISING THE SAME, AND METHOD OF CROSSLINKING WITH THE SAME
  申请人：NOF CORPORATION

  公开号：EP1233014A1

  公开（公告）日：2002-08-21

  A crosslinking agent comprising an asymmetry organic peroxide having at least one structure unit of (substituted)benzoylcarbonyloxy group represented by the following formula (1) in the molecule thereof. Environmentally friendly crosslinking agents and crosslinked silicone rubber moldings are provided thereby. Specifically, useful crosslinking agents and crosslinking processes for silicone rubber are provided.

  一种交联剂，包括至少具有分子中表示为以下式（1）的（取代）苯甲酰羰氧基结构单元的不对称有机过氧化物。因此提供了环保的交联剂和交联硅橡胶成型品。具体提供了用于硅橡胶的有用交联剂和交联工艺。
• Shape-retentive hydrogel particle aggregates and their uses
  申请人：——

  公开号：US20040086548A1

  公开（公告）日：2004-05-06

  The present invention is related to hydrogel particles and aggregates formed therefrom having characteristics including, without limitation, shape-retentiveness, elasticity, controllable pore sizes and controllable degradation rates that render them useful for a wide variety of applications including, without limitation, the controlled release of biologically active substances, in vivo medical devices, tissue growth scaffolding and tissue replacement.

  本发明涉及具有以下特征的水凝胶颗粒和聚集体，包括但不限于保持形状、具有弹性、可控的孔径大小和可控的降解速率，使它们适用于广泛的应用，包括但不限于生物活性物质的控制释放、体内医疗器械、组织生长支架和组织替代。
• SHAPE-RETENTIVE HYDROGEL PARTICLE AGGREGATES AND THEIR USES
  申请人：St. John John V.

  公开号：US20080166409A1

  公开（公告）日：2008-07-10

  The present invention is related to hydrogel particles and aggregates formed therefrom having characteristics including, without limitation, shape-retentiveness, elasticity, controllable pore sizes and controllable degradation rates that render them useful for a wide variety of applications including, without limitation, the controlled release of biologically active substances, in vivo medical devices, tissue growth scaffolding and tissue replacement.

  本发明涉及水凝胶颗粒及由其形成的聚集体，其特征包括但不限于形状保持性、弹性、可控孔径和可控降解速率，使它们在各种应用中有用，包括但不限于生物活性物质的控制释放、体内医疗器械、组织生长支架和组织替代。
• HYDROGEL WOUND DRESSING AND BIOMATERIALS FORMED IN SITU AND THEIR USES
  申请人：St. John John

  公开号：US20110123621A1

  公开（公告）日：2011-05-26

  The present invention relates to a method of forming shape-retentive and shape-conforming aggregate wound dressings and biomaterials composed of gel nanoparticles and wound or bodily fluid in which the aggregates are held together by non-covalent bond physical forces such as, without limitation, hydrophobic-hydrophilic interactions and hydrogen bonds. The method comprises introducing a dry powder of gel nanoparticles to a wound site in which the nanoparticles absorb some of the blood or wound exudate and coalesce in situ into the claimed shape-retentive aggregate dressing. The method also comprises introducing the dry nanoparticle powder in or on a wet bodily tissue in vivo to form the claimed shape-retentive biomaterial. In addition, the method also comprises incorporating biomedical agents to produce medicated aggregate dressings or biomaterials for a variety of medical applications. This invention also relates to uses of the method of formation of the shape-retentive aggregates of gel nanoparticles.

  本发明涉及一种形成保持形状和适应形状的聚集伤口敷料和生物材料的方法，其由凝胶纳米粒子和伤口或体液组成，这些聚集体由非共价键物理力保持在一起，例如，但不限于疏水-亲水相互作用和氢键。该方法包括将凝胶纳米粒子的干粉引入伤口部位，其中纳米粒子吸收一些血液或伤口渗出物，并在现场凝聚成所述的保持形状的聚集敷料。该方法还包括将干纳米粒子粉末引入或涂覆于体内湿润的组织中，以形成所述的保持形状的生物材料。此外，该方法还包括将生物医学剂合并进来，以生产用于各种医疗应用的医用聚集敷料或生物材料。本发明还涉及使用凝胶纳米粒子形成保持形状的聚集体的方法。
• Hydrogel wound dressing and biomaterials formed in situ and their uses
  申请人：John John ST.

  公开号：US20090196936A1

  公开（公告）日：2009-08-06

  The present invention relates to a method of forming shape-retentive and shape-conforming aggregate wound dressings and biomaterials composed of gel nanoparticles and wound or bodily fluid in which the aggregates are held together by non-covalent bond physical forces such as, without limitation, hydrophobic-hydrophilic interactions and hydrogen bonds. The method comprises introducing a dry powder of gel nanoparticles to a wound site in which the nanoparticles absorb some of the blood or wound exudate and coalesce in situ into the claimed shape-retentive aggregate dressing. The method also comprises introducing the dry nanoparticle powder in or on a wet bodily tissue in vivo to form the claimed shape-retentive biomaterial. In addition, the method also comprises incorporating biomedical agents to produce medicated aggregate dressings or biomaterials for a variety of medical applications. This invention also relates to uses of the method of formation of the shape-retentive aggregates of gel nanoparticles.

  本发明涉及一种形成保持形状和适应形状的集合伤口敷料和生物材料的方法，该生物材料由凝胶纳米颗粒和伤口或体液组成，其中集合体由非共价键物理力保持在一起，例如，疏水-亲水相互作用和氢键等。该方法包括将凝胶纳米颗粒的干粉引入伤口部位，在其中纳米颗粒吸收部分血液或伤口渗出物，并在原地凝聚成所述保持形状的集合敷料。该方法还包括将干纳米颗粒粉末引入或涂在体内的湿润组织上，以形成所述保持形状的生物材料。此外，该方法还包括将生物医学药剂并入其中，以生产用于各种医疗应用的医疗集合敷料或生物材料。本发明还涉及利用凝胶纳米颗粒形成保持形状的集合体的方法。