[Mn(lawsone)₂(H₂O)₂] | 1431160-10-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: [Mn(lawsone)₂(H₂O)₂]
• 英文别名: [Mn(Lw)₂(H₂O)₂]
• CAS: 1431160-10-9
• 化学式: C₂₀H₁₄MnO₈
• 分子量: 437.264
• InChiKey: IDSGWQRSFQSXGT-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  2-羟基-1,4-萘醌 、 manganese (II) acetate tetrahydrate 以 乙醇 为溶剂， 生成 [Mn(lawsone)₂(H₂O)₂]
  参考文献：
  名称：

  Synthesis and cytotoxic activity of metallic complexes of lawsone

  摘要：

  In the present study, a series of metallic complexes of the 1,4-naphthoquinone lawsone (2-6) were synthesized and evaluated for potential cytotoxicity in a mouse leukemic macrophagic RAW 264.7 cell line. Cell viability was determined by the MTT assay. Significant growth inhibition was observed for the copper complex (4) with an IC50 value of 2.5 mu M. This compound was selected for further evaluation of cytotoxic activity on several human cancer cells including HT-29 (human colorectal adenocarcinoma), HepG2 (human hepatocellular carcinoma) and HeLa, (human cervical adenocarcinoma cells). Significant cell viability decrease was also observed in HepG2 cells. The apoptotic potential of this complex was evaluated in these cells. Compound 4 induced apoptosis by a mechanism that involves the activation of caspases 3, 8 and 9 and modulation of apoptotic-related proteins such as Bax, Bad, and p53. These results indicate that metal complexes of lawsone derivatives, in particular compound 4, might be used for the design of new antitumoral agents. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2013.03.002

文献信息

• Metal complexes of ‘Heena’ (2-hydroxy-1,4-naphthoquinone): Synthesis, Characterization and anticancer activity
  作者：Nishigandha Mone、Shital Harihar、Sunita Salunke-Gawali、Surekha Satpute、Archana Patil、Vivek Mokashi、Mahesh Jadhav、Ray J. Butcher

  DOI：10.1016/j.ica.2022.121290

  日期：2023.2

  The Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes of Henna; 2-hydroxy-1,4-naphthoquinone (Lw) are synthesized at 0 °C (Mn2+; 1, Co2+; 2, Ni2+; 3, Cu2+; 4 and Zn2+; 5), 26 °C (Mn2+; 1A, Co2+; 2A, Ni2+; 3A, Cu2+; 4A and Zn2+; 5A) and characterized. The compositions of all complexes are of the type [M(Lw)2(H2O)2]. The geometry of the complexes synthesized at 26 °C is trans, whereas cis for complex

  Henna 的 Mn(II)、Co(II)、Ni(II)、Cu(II) 和 Zn(II) 络合物；2-羟基-1,4-萘醌 ( Lw ) 在 0 °C 下合成（Mn 2+ ; 1 , Co 2+ ; 2 , Ni 2+ ; 3 , Cu 2+ ; 4和 Zn 2+ ; 5）， 26 °C (Mn 2+ ; 1A , Co 2+ ; 2A , Ni 2+ ; 3A , Cu 2+ ; 4A和 Zn 2+ ; 5A) 和特征。所有配合物的组成都是[M(Lw) 2 (H 2 O) 2 ]类型。在 26 °C 下合成的复合物的几何结构为反式，而在 0 °C 下复合物4为顺式。铜配合物4A的吡啶加合物 ( 4Apy ) 和配合物4的甲醇 ( 4MeOH ) 加合物通过单晶 X 射线衍射研究表征。从2A、5A、4Apy和4MeOH的 X 射线结构揭示了分子相互作用. 针对两种癌细胞系 MCF-7（乳腺癌细胞系）和