2-(2,3-Diaminophenyl)acetic acid | 1695209-76-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2,3-Diaminophenyl)acetic acid
• CAS: 1695209-76-7
• 化学式: C₈H₁₀N₂O₂
• mdl: MFCD22480928
• 分子量: 166.18
• InChiKey: FIYNNIMRGIRYEO-UHFFFAOYSA-N

物化性质

• 沸点：
  408.4±30.0 °C(Predicted)
• 密度：
  1.368±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.125
• 拓扑面积：
  89.3
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] SUBSTITUTED BENZIMIDAZOLES, BENZOTHIAZOLES AND BENZOXAZOLES<br/>[FR] BENZIMIDAZOLES, BENZOTHIAZOLES ET BENZOXAZOLES SUBSTITUÉS
  申请人：GRUENENTHAL GMBH

  公开号：WO2010142402A1

  公开（公告）日：2010-12-16

  The present invention relates to substituted benzimidazoles, benzothiazoles and benzoxazoles, processes for their preparation, medicaments containing these compounds and the use of these compounds for the preparation of medicaments.

  本发明涉及取代苯并咪唑、苯并噻唑和苯并噁唑，其制备方法，含有这些化合物的药物以及利用这些化合物制备药物的用途。
• NON-NUCLEOSIDE ANTI-HEPACIVIRUS AGENTS AND USES THEREOF
  申请人：Boyd A. Vincent

  公开号：US20070021434A1

  公开（公告）日：2007-01-25

  The present dislcosure provides amide-based, non-nucleoside compounds having antiviral activity against Hepacivirus, such as hepatitis C virus (HCV), methods and intermediates for synthesizing such compounds, and methods of using the compounds in a variety of contexts, including in the treatment and prevention of viral infections. The present dislcosure also provides methods for identifying amide-based, non-nucleoside compounds having antiviral activity.

  本公开提供了基于酰胺的非核苷类化合物，具有抗Hepacivirus活性，例如丙型肝炎病毒（HCV），合成这类化合物的方法和中间体，以及在各种情境中使用这些化合物的方法，包括在治疗和预防病毒感染中的应用。本公开还提供了识别具有抗病毒活性的基于酰胺的非核苷类化合物的方法。
• COMPOSITIONS AND METHODS FOR TREATING HYPERPROLIFERATIVE DISEASE
  申请人：Cameron Dale Russell

  公开号：US20080171783A1

  公开（公告）日：2008-07-17

  The present disclosure provides amide-based, non-nucleoside compounds having an inhibitory activity against endogenous polymerases, such as polymerase alpha and polymerase gamma. This disclosure further provides uses of treating hyperproliferative diseases or disorders, such as benign or malignant neoplasms, and more specifically cancers that are sensitive to inhibition of polymerase alpha and polymerase gamma.

  本公开提供了基于酰胺的非核苷类化合物，具有对内源聚合酶（如聚合酶α和聚合酶γ）的抑制活性。本公开进一步提供了用于治疗过度增殖性疾病或疾病的用途，例如良性或恶性肿瘤，更具体地是对聚合酶α和聚合酶γ抑制敏感的癌症。
• Compositions of lipopeptide antibiotic derivatives and methods of use thereof
  申请人：Cameron R. Dale

  公开号：US20050153876A1

  公开（公告）日：2005-07-14

  The present invention provides derivatives of lipopeptide antibiotics that display antimicrobial activity against microorganisms, methods and compounds for synthesizing such antimicrobial derivatives and analogues, and methods of using the compounds in a variety of contexts, including in the treatment and prevention of microbial infections.

  本发明提供了脂肽类抗生素的衍生物，对微生物显示出抗菌活性，包括合成这种抗微生物衍生物和类似物的方法和化合物，以及在多种情况下使用这些化合物的方法，包括在治疗和预防微生物感染中使用。
• CHIP FOR SAMPLING CELL COMPONENT, SYSTEM FOR ANALYZING CELL COMPONENT AND METHOD OF ANALYZING CELL COMPONENT USING THE SAME
  申请人：On-chip Cellomics Consortium

  公开号：EP2130913A1

  公开（公告）日：2009-12-09

  The present invention provides a method, a chip device, and a system for quantitatively measuring intercellularly and intracellularly-localized mRNA and protein without loss of local space information. In the present invention, cell content is trapped atop a substrate or an electrode in the form of a two-dimensional projection of a cell. Accordingly, electrophoretic force is used, or the cellular moisture content is instantaneously evaporated and immobilized. mRNA immobilized to a two-dimensional surface is identified with a labeled probe which hybridizes to the mRNA.

  本发明提供了一种方法、芯片装置和系统，用于定量测量细胞间和细胞内定位的 mRNA 和蛋白质，而不会丢失局部空间信息。在本发明中，细胞内容物以细胞二维投影的形式被困在基底或电极上。固定在二维表面的 mRNA 可通过与 mRNA 杂交的标记探针进行识别。