2-[5-chloro-2-(7,7a,8,9,10,11-hexahydro-5H-6-oxa-11a-aza-dibenzo[a,c]cyclohepten-3-ylamino)-pyrimidin-4-ylamino]-N-methyl-benzamide | 1022955-09-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 2-[5-chloro-2-(7,7a,8,9,10,11-hexahydro-5H-6-oxa-11a-aza-dibenzo[a,c]cyclohepten-3-ylamino)-pyrimidin-4-ylamino]-N-methyl-benzamide
• 英文别名: 2-[[2-(2,3,4,4a,5,7-hexahydro-1H-pyrido[1,2-a][4,1]benzoxazepin-9-ylamino)-5-chloropyrimidin-4-yl]amino]-N-methylbenzamide
• CAS: 1022955-09-4
• 化学式: C₂₅H₂₇ClN₆O₂
• 分子量: 478.981
• InChiKey: WTONLHWJXXNKQO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  91.4
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND c-MET INHIBITORS
  申请人：Ahmed Gulzar

  公开号：US20090221555A1

  公开（公告）日：2009-09-03

  The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , A 1 , A 2 , A 3 , A 4 , and A 5 , are as defined herein. The compounds of formula I or II have ALK and/or c-Met inhibitory activity, and may be used to treat proliferative disorders.

  本发明提供公式I或II化合物或其药学上可接受的盐形式，其中R1、R2、R3、R4、R5、A1、A2、A3、A4和A5如本文所定义。公式I或II化合物具有ALK和/或c-Met抑制活性，可用于治疗增殖性疾病。
• Fused Bicyclic Derivatives of 2,4-Diaminopyrimidine as ALK and c-MET Inhibitors
  申请人：Ahmed Gulzar

  公开号：US20120165519A1

  公开（公告）日：2012-06-28

  The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , A 1 , A 2 , A 3 , A 4 , and A 5 , are as defined herein. The compounds of formula I or II have ALK and/or c-Met inhibitory activity, and may be used to treat proliferative disorders.

  本发明提供了式I或II的化合物或其药学上可接受的盐形式，其中R1、R2、R3、R4、R5、A1、A2、A3、A4和A5如本文所定义。式I或II的化合物具有ALK和/或c-Met抑制活性，并可用于治疗增生性疾病。
• FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS
  申请人：Cephalon, Inc.

  公开号：EP2222647B1

  公开（公告）日：2015-08-05
• Fused bicyclic derivatives of 2,4-diaminopyrimidine as alk and C-met inhibitors
  申请人：Cephalon, Inc.

  公开号：EP2684874B1

  公开（公告）日：2017-05-17
• US8148391B2
  申请人：——

  公开号：US8148391B2

  公开（公告）日：2012-04-03