(S)-3-<2-(Acetyloxy)-1-phenylethyl>-6-methyl-3,6-diazabicyclo<3.1.0>hexane-2,4-dione | 120566-72-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: (S)-3-<2-(Acetyloxy)-1-phenylethyl>-6-methyl-3,6-diazabicyclo<3.1.0>hexane-2,4-dione
• CAS: 120566-72-5
• 化学式: C₁₅H₁₆N₂O₄
• 分子量: 288.303
• InChiKey: YEVJGPNTRYPEHE-MPXNVAGNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.34
• 重原子数：
  21.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  66.69
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  (S)-3-<2-(Acetyloxy)-1-phenylethyl>-6-methyl-3,6-diazabicyclo<3.1.0>hexane-2,4-dione 、 (2S)-N-(acryloyl)bornane-10,2-sultam 以 1,4-二氧六环 为溶剂， 以55%的产率得到Acetic acid (S)-2-[(1R,5S,6R)-6-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-8-methyl-2,4-dioxo-3,8-diaza-bicyclo[3.2.1]oct-3-yl]-2-phenyl-ethyl ester
  参考文献：
  名称：

  Stereoselective 1,3-dipolar cycloadditions of photochemically generated azomethine ylides to Oppolzer's chiral acryloyl sultam. An asymmetric approach to quinocarcin

  摘要：

  DOI：

  10.1021/jo00300a004
• 作为产物：
  描述：

  5-<(S)-2-(Acetyloxy)-1-phenylethyl>-3a,6a-dihydro-1-methylpyrrolo<3,4-d>-1,2,3-triazole-4,6(1H,5H)-dione 以 1,4-二氧六环 为溶剂， 反应 5.0h， 以90%的产率得到(S)-3-<2-(Acetyloxy)-1-phenylethyl>-6-methyl-3,6-diazabicyclo<3.1.0>hexane-2,4-dione
  参考文献：
  名称：

  Development of an asymmetric approach to the 3,8-diazabicyclo[3.2.1]octane moiety of quinocarcin via intramolecular 1,3-dipolar cycloadditions of photochemically generated azomethine ylides

  摘要：

  Exploratory work culminating in an enantioselective approach to the DNA-reactive alkaloid quinocarcin (1) is detailed. The key step involves auxiliary-controlled dipolar cycloaddition between photochemically generated azomethine ylides such as 11 and Oppolzer's chiral acryloyl sultam (-)-32 to assemble the 6-exo-substituted 3,8-diazabicyclo[3.2.1]octane core of 1. The synthetic sequence begins with condensation of the benzylamines 3 and maleic anhydride to give the N-alkylated maleimides 6. Triazoline formation (MeN3) followed by photolytic (lambda > 3000 angstrom) extrusion of nitrogen leads to the corresponding aziridines 10. Upon irradiation at 2537 angstrom, these aziridines undergo electrocyclic ring-opening to give azomethine ylides 11, which can be trapped with (-)-32 to give the 6-exo-substituted cycloadduct 33 (diastereoselectivity, ds > 25:1). These results stand in sharp contrast to cycloadditions of 11 with (achiral and chiral) acrylate ester dipolarophiles as well as acrylonitrile, which proceed with no appreciable facial selectivity. The expected re-face selectivity of (-)-32 was confirmed in one case by X-ray crystallographic analysis of endo-adduct 35a. Removal (and recovery) of the chiral sultam auxiliary can be effected by titanium (IV)-mediated alcoholysis to give ester derivatives of the cycloadducts.

  DOI：

  10.1021/jo00020a035