4-benzhydryloxy-2,2,6,6-tetramethylpiperidine hydrochloric acid salt | 1186529-80-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-benzhydryloxy-2,2,6,6-tetramethylpiperidine hydrochloric acid salt
• 英文别名: 4-Benzhydryloxy-2,2,6,6-tetramethylpiperidine;hydrochloride
• CAS: 1186529-80-5
• 化学式: C₂₂H₂₉NO*ClH
• 分子量: 359.939
• InChiKey: VEYUTLAXFOAXJW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.52
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  21.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• NOVEL 4-BENZHYDRYLOXY-TETRAALKYL-PIPERIDINE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS
  申请人：Peters Dan

  公开号：US20110053984A1

  公开（公告）日：2011-03-03

  This invention relates to novel 4-benzhydryloxy-tetraalkyl-piperidine derivatives of Formula (I), any of its stereoisomers or any mixture of its stereoisomers, or an N-oxide thereof, or a pharmaceutically acceptable salt thereof, wherein R a represents hydrogen or C 1-6 -alkyl; R b and R c independent of each other represent a phenyl group, which phenyl group is optionally substituted with one or more substituents independently selected from the group consisting of halo, trifluoromethyl, trifluoromethoxy, cyano, C 1-6 -alkoxy and methylenedioxo; R′, R″, R′″ and R″″ independent of each other represent C 1-6 -alkyl; and with the proviso that the compound is not 4-benzhydryloxy-1,2,2,6,6-pentamethyl-piperidine, useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

  本发明涉及一种新型的4-苯甲酰氧基-四烷基-哌啶衍生物，其化学式为（I），包括其任何立体异构体或其立体异构体的混合物，或其N-氧化物或其药学上可接受的盐，其中，R代表氢或C1-6-烷基；Rb和Rc独立地表示苯基，所述苯基可以选自卤素、三氟甲基、三氟甲氧基、氰基、C1-6-烷氧基和亚甲基二氧基等基团中的一个或多个置换；R'、R"、R'"和R""独立地表示C1-6-烷基；但该化合物不是4-苯甲酰氧基-1,2,2,6,6-五甲基-哌啶，有用作单胺神经递质再摄取抑制剂。在其他方面，本发明涉及使用这些化合物的治疗方法以及包括本发明化合物的药物组合物。