3-({3-[{3-[Benzyl-(9H-fluoren-9-ylmethoxycarbonyl)-amino]-propionyl}-(3-dimethylamino-propyl)-amino]-propionyl}-isobutyl-amino)-propionic acid | 879573-65-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 3-({3-[{3-[Benzyl-(9H-fluoren-9-ylmethoxycarbonyl)-amino]-propionyl}-(3-dimethylamino-propyl)-amino]-propionyl}-isobutyl-amino)-propionic acid
• CAS: 879573-65-6
• 化学式: C₄₀H₅₂N₄O₆
• 分子量: 684.876
• InChiKey: XSLPXMPDXVBZTO-UHFFFAOYSA-N

物化性质

• 沸点：
  841.0±65.0 °C(Predicted)
• 密度：
  1.176±0.06 g/cm3(Predicted)

反应信息

• 作为反应物：
  描述：

  3-({3-[{3-[Benzyl-(9H-fluoren-9-ylmethoxycarbonyl)-amino]-propionyl}-(3-dimethylamino-propyl)-amino]-propionyl}-isobutyl-amino)-propionic acid 、 乙酸酐 、 alkaline earth salt of/the/ methylsulfuric acid 生成 (2S)-2-[3-[3-[3-[3-[3-[3-[3-[3-[3-[acetyl(benzyl)amino]propanoyl-[3-(dimethylamino)propyl]amino]propanoyl-(2-methylpropyl)amino]propanoyl-benzylamino]propanoyl-[3-(dimethylamino)propyl]amino]propanoyl-(2-methylpropyl)amino]propanoyl-benzylamino]propanoyl-[3-(dimethylamino)propyl]amino]propanoyl-(2-methylpropyl)amino]propanoylamino]-6-aminohexanamide
  参考文献：
  名称：

  Antimicrobial β-peptoids by a block synthesis approach

  摘要：

  Antimicrobial peptides and their mimetics offer a potential new disinfective tool. beta-Peptoids (oligo-N-substituted beta-alanines) were synthesized and investigated for antimicrobial activity. A block approach whereby di- and tri-beta-peptoids were first prepared and then ligated via amide bond formation to synthesize larger beta-peptoids was developed. The beta-peptoids were found to possess moderate activity in an Escheridchia coli assay. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.11.075
• 作为产物：
  描述：

  3-({3-[{3-[Benzyl-(9H-fluoren-9-ylmethoxycarbonyl)-amino]-propionyl}-(3-dimethylamino-propyl)-amino]-propionyl}-isobutyl-amino)-propionic acid tert-butyl ester 在 甲酸 作用下， 反应 12.0h， 生成 3-({3-[{3-[Benzyl-(9H-fluoren-9-ylmethoxycarbonyl)-amino]-propionyl}-(3-dimethylamino-propyl)-amino]-propionyl}-isobutyl-amino)-propionic acid
  参考文献：
  名称：

  Antimicrobial β-peptoids by a block synthesis approach

  摘要：

  Antimicrobial peptides and their mimetics offer a potential new disinfective tool. beta-Peptoids (oligo-N-substituted beta-alanines) were synthesized and investigated for antimicrobial activity. A block approach whereby di- and tri-beta-peptoids were first prepared and then ligated via amide bond formation to synthesize larger beta-peptoids was developed. The beta-peptoids were found to possess moderate activity in an Escheridchia coli assay. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.11.075