6-methoxy-4-[3-(6-methyl-pyridyn-2-yl)-isoxazol-4-yl]-quinoline | 676256-23-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-methoxy-4-[3-(6-methyl-pyridyn-2-yl)-isoxazol-4-yl]-quinoline
• 英文别名: 4-(6-Methoxyquinolin-4-yl)-3-(6-methylpyridin-2-yl)-1,2-oxazole
• CAS: 676256-23-8
• 化学式: C₁₉H₁₅N₃O₂
• 分子量: 317.347
• InChiKey: COISSWUYKFWILM-UHFFFAOYSA-N

物化性质

• 沸点：
  474.5±45.0 °C(Predicted)
• 密度：
  1.235±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  61
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] NOVEL ISOTHIAZOLE AND ISOXAZOLE COMPOUNDS AS TRANSFORMING GROWTH FACTOR (TGF) INHIBITORS<br/>[FR] NOUVEAUX COMPOSES D'ISOTHIAZOLE ET D'ISOXAZOLE UTILISES COMME INHIBITEURS DU FACTEUR DE CROISSANCE TRANSFORMANT (TGF)
  申请人：PFIZER PROD INC

  公开号：WO2004026865A1

  公开（公告）日：2004-04-01

  Novel isothiazole and isoxazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor ('TGF')-P signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer, and fibrotic diseases.

  本发明涉及新型的异噻唑和异噁唑化合物及其衍生物，以及其制备中间体、含有它们的制药组合物和它们的药用。本发明的化合物是转化生长因子（“TGF”）-P信号通路的有效抑制剂。它们在治疗各种TGF相关疾病状态中具有用途，包括癌症和纤维性疾病等。
• NOVEL ISOTHIAZOLE AND ISOXAZOLE COMPOUNDS AS TRANSFORMING GROWTH FACTOR (TGF) INHIBITORS
  申请人：Pfizer Products Inc.

  公开号：EP1542995A1

  公开（公告）日：2005-06-22
• Novel isothiazole and isoxazole compounds as transforming growth factor (TGF) inhibitors
  申请人：Pfizer Inc

  公开号：US20040116473A1

  公开（公告）日：2004-06-17

  Novel isothiazole and isoxazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor (“TGF”)-&bgr; signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer, and fibrotic diseases.
• US7030125B2
  申请人：——

  公开号：US7030125B2

  公开（公告）日：2006-04-18