2-[1-(3,5-difluorophenylacetamido)ethyl]-4-methoxycarbonyl-4-phenyl-2-imidazoline | 213025-25-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[1-(3,5-difluorophenylacetamido)ethyl]-4-methoxycarbonyl-4-phenyl-2-imidazoline
• 英文别名: methyl 2-[1-[[2-(3,5-difluorophenyl)acetyl]amino]ethyl]-5-phenyl-1,4-dihydroimidazole-5-carboxylate
• CAS: 213025-25-3
• 化学式: C₂₁H₂₁F₂N₃O₃
• 分子量: 401.413
• InChiKey: VRGDMTDTSATYAB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  79.8
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3,5-二氟苯乙酸 、 2-(1-Aminoethyl)-1-tert-butoxycarbonyl-4-methoxycarbonyl-4-phenyl-2-imidazoline 、 、 生成 2-[1-(3,5-difluorophenylacetamido)ethyl]-4-methoxycarbonyl-4-phenyl-2-imidazoline
  参考文献：
  名称：

  Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds

  摘要：

  本发明涉及一种抑制β-淀粉样肽释放和/或合成的化合物，因此具有治疗阿尔茨海默病的效用。本发明还涉及包含抑制β-淀粉样肽释放和/或合成的化合物的药物组合物，以及使用这种药物组合物预防和治疗阿尔茨海默病的方法。

  公开号：

  US06849650B2

文献信息

• Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
  申请人：——

  公开号：US20030130188A1

  公开（公告）日：2003-07-10

  Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

  本发明揭示了一些化合物，可以抑制&bgr;-淀粉样肽的释放和/或合成，因此在治疗阿尔茨海默病方面具有实用性。本发明还揭示了包含抑制&bgr;-淀粉样肽释放和/或合成的化合物的制药组合物，以及使用这些制药组合物预防和治疗阿尔茨海默病的方法。
• Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting &bgr;-amyloid peptide release and/or its synthesis by use of such compounds
  申请人：Athena Neurosciences, Inc.

  公开号：US06506782B1

  公开（公告）日：2003-01-14

  Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

  本发明揭示了一种抑制β-淀粉样肽释放和/或其合成的化合物，因此在治疗阿尔茨海默病方面具有实用性。还揭示了包含抑制β-淀粉样肽释放和/或其合成的化合物的药物组合物，以及使用这种药物组合物预防和治疗阿尔茨海默病的方法。
• Novel polymer compound, composition containing the compound, ink composition, ink-applying method, and ink-applying apparatus
  申请人：Nakazawa Ikuo

  公开号：US20050239918A1

  公开（公告）日：2005-10-27

  A block copolymer comprises three block segments of a first segment, a second segment, and a third segment, and containing a polyalkenyl ether main chain, wherein the first segment is hydrophilic or hydrophobic, the second segment is hydrophobic, and the third segment is ionic; and at least one of the block segments has a structure represented by General Formula (1) below: —(CRaRb-CRc(OR 1 ))—  ( 1 ) wherein Ra, Rb, and Rc are respectively H or CH 3 ; R 1 is selected from the group consisting of linear, branched, or cyclic alkyl groups of 1 to 18 carbon atoms, —(CH(R 2 )—CH(R 3 )—O) l —R 4 , and —(CH 2 ) m —(O) n —R 4 ; l and m are an integer from 1 to 12; n is 0 or 1; R 2 and R 3 are H or CH 3 ; R 4 is selected from the group consisting of H, linear, branched or cyclic alkyl groups of 1 to 6 carbon atoms, -Ph, -Pyr, -Ph-Ph, -Ph-Pyr, —CHO, —CH 2 CHO, —CO—CH═CH 2 , —CO—C(CH 3 )═CH 2 , —CH 2 COOR 5 , -PhCOOR 5 , —CH 2 SO 3 R 5 , and -PhSO 3 R 5 ; the hydrogen on the carbon atoms constituting R 4 except R 5 moiety may be replaced by a linear or branched alkyl group of 1 to 4 carbon atoms, and the carbon in the aromatic ring may be replaced by nitrogen; and R 5 is H, an alkyl group of 1 to 5 carbon atoms, or mono- or higher-valent cation.

  一种嵌段共聚物包含三个嵌段，分别为第一嵌段、第二嵌段和第三嵌段，并含有聚烯醚主链，其中第一嵌段亲水或疏水，第二嵌段疏水，第三嵌段离子；且至少一个嵌段具有下式（1）表示的结构： -(CRaRb-CRc(OR 1 ))- ( 1 ) 其中 Ra、Rb 和 Rc 分别为 H 或 CH 3 ; R 1 选自由 1 至 18 个碳原子的直链、支链或环状烷基、-(CH(R 2 )-CH(R 3 )-O) l -R 4 和-(CH 2 ) m -(O) n -R 4 l 和 m 是 1 到 12 之间的整数；n 是 0 或 1；R 2 和 R 3 是 H 或 CH 3 ; R 4 选自由 H、1-6 个碳原子的直链、支链或环状烷基、-Ph、-Pyr、-Ph-Ph、-Ph-Pyr、-CHO、-CH 2 CHO、-CO-CH═CH 2 、-CO-C(CH 3 ）═CH 2 , -CH 2 COOR 5 , -PhCOOR 5 , -CH 2 SO 3 R 5 和-PhSO 3 R 5 的碳原子上的氢。 4 除 R 5 可由 1 至 4 个碳原子的直链或支链烷基取代，芳香环中的碳可由氮取代；以及 R 5 是 H、1 至 5 个碳原子的烷基或单价或高价阳离子。
• HETEROCYCLIC COMPOUNDS AND THEIR USE FOR INHIBITING $g(b)-AMYLOID PEPTIDE
  申请人：Elan Pharmaceuticals, Inc.

  公开号：EP0968198A1

  公开（公告）日：2000-01-05
• JP2001513107A
  申请人：——

  公开号：JP2001513107A

  公开（公告）日：2001-08-28