Phenyl-4-tert.-butylaminophenyl-aether | 54794-91-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Phenyl-4-tert.-butylaminophenyl-aether
• 英文别名: N-tert-butyl-4-phenoxyaniline
• CAS: 54794-91-1
• 化学式: C₁₆H₁₉NO
• 分子量: 241.333
• InChiKey: TVEPNNGPDQDDKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• IMMUNOREGULATORY AGENTS
  申请人：Flexus Biosciences, Inc.

  公开号：US20170197973A1

  公开（公告）日：2017-07-13

  Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

  本文描述了调节氧化还原酶酶indoleamine 2,3-dioxygenase的化合物和含有这些化合物的组合物。还提供了使用这些化合物和组合物治疗和/或预防各种疾病、障碍和病况，包括由indoleamine 2,3-dioxygenase介导的癌症和免疫相关障碍。
• HYDROXYINDOLE CARBOXYLIC ACID BASED INHIBITORS FOR ONCOGENIC SRC HOMOLOGY-2 DOMAIN CONTAINING PROTEIN TYROSINE PHOSPHATASE-2 (SHP2)
  申请人：INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION

  公开号：US20160102054A1

  公开（公告）日：2016-04-14

  Inhibitors of protein tyrosine phosphatases are disclosed. The inhibitors include hydroxyindole carboxylic acids having a linker and an amine scaffold that are potent inhibitors of Src homology 2-domain containing protein tyrosine phosphatase-2.

  本发明公开了蛋白酪氨酸磷酸酶的抑制剂。这些抑制剂包括具有连接基和胺支架的羟基吲哚羧酸，它们是Src同源2-含有蛋白酪氨酸磷酸酶的有效抑制剂。
• N-t-BUTYLANILINE ANALOG AND LIPID LEVEL DEPRESSANT CONTAINING THE SAME
  申请人：TAISHO PHARMACEUTICAL CO. LTD

  公开号：EP0666253A1

  公开（公告）日：1995-08-09

  An N-t-butylaniline analog represented by general formula (I) or a salt thereof, and a lipid level depressant containing the same as the active ingredient. In said formula, R¹ and R², which may be the same or different from each other, represent each hydrogen, halogen, amino, nitro, acetamide, lower alkyl, lower alkoxy, halogenated lower alkyl, halogenated lower alkoxy or lower alkanoyl; R³ represents hydrogen, halogen, lower alkoxy or halogenated lower alkyl; and Z represents S, SO or SO₂. This compound has a remarkably excellent effect of depressing the lipid level as compared with clofibrate and 4-(N-t-butyl)methanesulfonylaminodiphenyl ether and is extremely reduced in toxicity.

  一种由通式(I)代表的N-叔丁基苯胺类似物或其盐，以及一种含有相同活性成分的血脂水平抑制剂。在所述通式中，R¹和R²可以相同或不同，分别代表氢、卤素、氨基、硝基、乙酰胺、低级烷基、低级烷氧基、卤代低级烷基、卤代低级烷氧基或低级烷酰基；R³代表氢、卤素、低级烷氧基或卤代低级烷基；Z代表S、SO或SO₂。与氯贝特和 4-(N-叔丁基)甲磺酰氨基二苯醚相比，这种化合物具有显著的降脂效果，而且毒性极低。
• IDO inhibitors
  申请人：Bristol-Myers Squibb Company

  公开号：US10689331B2

  公开（公告）日：2020-06-23

  There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

  本发明公开了调节或抑制吲哚胺-2,3-二氧化酶（IDO）酶活性的化合物、含有上述化合物的药物组合物以及利用本发明化合物治疗增殖性疾病（如癌症、病毒感染和/或炎症性疾病）的方法。
• JPS62126155A
  申请人：——

  公开号：JPS62126155A

  公开（公告）日：1987-06-08