纽帕泛 | 139133-27-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 纽帕泛
• 英文名称: Nupafant
• 英文别名: N-[(2S)-1-ethoxy-4-methylpentan-2-yl]-N-methyl-4-[(2-methylimidazo[4,5-c]pyridin-1-yl)methyl]benzenesulfonamide
• CAS: 139133-27-0
• 化学式: C₂₃H₃₂N₄O₃S
• 分子量: 444.6
• InChiKey: GFUNPHNHBVCVHW-FQEVSTJZSA-N

物化性质

• 沸点：
  622.2±65.0 °C(Predicted)
• 密度：
  1.20±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  31
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  85.7
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Dendrimers as molecular translocators
  申请人：Goodman Murray

  公开号：US20060216265A1

  公开（公告）日：2006-09-28

  Transport molecules include a dendrimer and a biologically active molecule. The dendrimer of such transport molecules includes at least one guanidine group, at least one protonated guanidine group, at least one protected guanidine group, at least one amidine group, at least one protonated amidine group, at least one protected amidine group, at least one ureido group, at least one protonated ureido group, at least one protected ureido group, at least one thioureido group, at least one protonated thioureido group, or at least one protected thioureido group. The biologically active molecule is bonded to the dendrimer. A method of increasing the bioavailability of a drug includes bonding the drug to a dendrimer of the invention.

  转运分子包括一种树枝状聚合物和一种生物活性分子。这些转运分子的树枝状聚合物包括至少一个胍基团、至少一个质子化的胍基团、至少一个保护的胍基团、至少一个酰胺基团、至少一个质子化的酰胺基团、至少一个保护的酰胺基团、至少一个脲基团、至少一个质子化的脲基团、至少一个保护的脲基团、至少一个硫脲基团、至少一个质子化的硫脲基团，或至少一个保护的硫脲基团。生物活性分子与树枝状聚合物结合。一种增加药物生物利用度的方法包括将药物与本发明的树枝状聚合物结合。
• [EN] 7-MEMBERED AZA-HETEROCYCLIC CONTAINING DELTA-OPIOID RECEPTOR MODULATING COMPOUNDS, METHODS OF USING AND MAKING THE SAME<br/>[FR] COMPOSÉS MODULATEURS DU RÉCEPTEUR DES OPIOÏDES DELTA CONTENANT DES HÉTÉROCYCLES AZA À 7 CHAÎNONS, ET LEURS PROCÉDÉS DE PRÉPARATION ET D'UTILISATION
  申请人：TREVENA INC

  公开号：WO2018152286A1

  公开（公告）日：2018-08-23

  The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

  本实施例部分涉及化合物、其药用盐，或用于调节δ阿片受体活性的药物组合物，包括有偏倚和/或无偏倚的组合物，以及用于治疗疼痛、偏头痛、头痛、抑郁症、帕金森病、焦虑症、过度活跃膀胱以及其他在本文中描述的紊乱和症状的方法，或其中的任何组合。
• [EN] 5-MEMBERED AZA-HETEROCYCLIC CONTAINING DELTA-OPIOID RECEPTOR MODULATING COMPOUNDS, METHODS OF USING AND MAKING THE SAME<br/>[FR] COMPOSÉS MODULATEURS DU RÉCEPTEUR DELTA DES OPIOÏDES CONTENANT DES AZA-HÉTÉROCYCLES À 5 CHAÎNONS, LEURS PROCÉDÉS D'UTILISATION ET DE FABRICATION
  申请人：TREVENA INC

  公开号：WO2018152293A1

  公开（公告）日：2018-08-23

  The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

  本实施例部分涉及化合物、其药用可接受盐、或用于调节δ阿片受体活性的药物组合物，包括有偏向性和/或无偏向性的组合物，以及用于治疗疼痛、偏头痛、头痛、抑郁症、帕金森病、焦虑和/或膀胱过度活跃等疾病和症状的方法，以及本文中描述的其他疾病和症状或任何其组合。
• Hybrid Compounds And Methods Of Making And Using The Same
  申请人：Pan Wenxi

  公开号：US20140171438A1

  公开（公告）日：2014-06-19

  The present disclosure provides compounds, or pharmaceutically acceptable salts thereof, for inhibiting the growth of a microbe; treating a mammal having a microbial infection, malaria, mucositis, an ophthalmic infection, an otic infection, a cancer, or a Mycobacterium infection; killing or inhibiting the growth of a Plasmodium species; inhibiting the growth of a Mycobacterium species; modulating an immune response in a mammal; or antagonizing unfractionated heparin, low molecular weight heparin, or a heparin/low molecular weight heparin derivative.

  本公开提供化合物或其药学上可接受的盐，用于抑制微生物的生长；治疗患有微生物感染、疟疾、粘膜炎、眼部感染、耳部感染、癌症或分枝杆菌感染的哺乳动物；杀灭或抑制疟原虫的生长；抑制分枝杆菌的生长；调节哺乳动物的免疫反应；或对抗非分馏肝素、低分子量肝素或肝素/低分子量肝素衍生物。
• [EN] CYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME<br/>[FR] COMPOSÉS CYCLIQUES ET LEURS PROCÉDÉS DE FABRICATION ET D'UTILISATION
  申请人：POLYMEDIX INC

  公开号：WO2013090185A1

  公开（公告）日：2013-06-20

  The present invention provides compounds, or pharmaceutically acceptable salts thereof, for inhibiting the growth of a microbe; treating a mammal having a microbial infection, mucositis, an ophthalmic infection, an otic infection, a cancer, or a Mycobacterium infection; inhibiting the growth of a Mycobacterium species; modulating an immune response in a mammal; or antagonizing unfractionated heparin, low molecular weight heparin, or a heparin/low molecular weight heparin derivative.

  本发明提供了用于抑制微生物生长的化合物或其药学上可接受的盐；用于治疗患有微生物感染、口腔炎、眼科感染、耳科感染、癌症或结核分枝杆菌感染的哺乳动物；用于抑制结核分枝杆菌物种的生长；用于调节哺乳动物的免疫反应；或用于拮抗非分级肝素、低分子肝素或肝素/低分子肝素衍生物。