| 1240609-18-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮
• CAS: 1240609-18-0
• 化学式: C₄₁H₅₁N₃O₄S₂
• 分子量: 714.006
• InChiKey: KRADHXOJYKMCFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.71
• 重原子数：
  50.0
• 可旋转键数：
  22.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  59.34
• 氢给体数：
  1.0
• 氢受体数：
  9.0

反应信息

• 作为产物：
  描述：

  4-(5-(3-bromopropoxy)benzofuran-2-yl)-N,N-dimethylaniline 、 N,N'-bis-[2-(4-methoxy-benzylsulfanyl)-ethyl]-ethylenediamine 在 N,N-二异丙基乙胺 作用下， 以 乙腈 为溶剂， 生成
  参考文献：
  名称：

  Novel Benzofurans with ^99mTc Complexes as Probes for Imaging Cerebral β-Amyloid Plaques

  摘要：

  Two novel benzofuran derivatives coupled with Tc-99m complexes were tested as probes for imaging cerebral beta-amyloid plaques using single photon emission tomography. Although both derivatives bound to A beta(1-42) aggregates, Tc-99m-BAT-BF showed higher affinity than. Tc-99m-MAMA-BF. In sections of brain tissue from an animal model of AD, Tc-99m-BAT-BF clearly labeled beta-amyloid plaques in biodistribution experiments using normal mice Tc-99m-BAT-BF displayed high uptake soon after its injection and washed out from the brain rapidly, a highly desirable feature for an imaging agent. Tc-99m-BAT-BF may be a potential probe for imaging beta-amyloid plaques in Alzheimer's brains.

  DOI：

  10.1021/ml100140d