线粒体融合启动子M1 | 219315-22-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 线粒体融合启动子M1
• 英文名称: 4-chloro-2-[C-methyl-N-(2,4,6-trichloroanilino)carbonimidoyl]phenol
• CAS: 219315-22-7
• 化学式: C₁₄H₁₀Cl₄N₂O
• 分子量: 364.0
• InChiKey: CYVDGZYJHHYIIU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  44.6
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• METHODS AND COMPOSITIONS FOR RAPIDLY DECREASING EPIGENETIC AGE AND RESTORATION OF MORE YOUTHFUL FUNCTION
  申请人：Dischler Louis

  公开号：US20200054061A1

  公开（公告）日：2020-02-20

  Disclosed are methods and compositions of reducing the epigenetic age of mammalian organism, especially an adult human of geriatric age. The methods provide for the proliferation of endogenous stem cells using mitochondrial fusion and a UCP2 blocker or other stimulants; supplying stem cells with nutrition to prevent cell cycle arrest; and removal of senescent somatic cells using senolytic treatments. The proliferation of endogenous neural stem cells after plaque removal for the treatment of Alzheimer's is also disclosed.

  揭示了减少哺乳动物生物体表观遗传年龄的方法和组合物，尤其是老年人类成年人的方法。该方法通过使用线粒体融合和UCP2阻断剂或其他刺激剂促进内源干细胞的增殖；为干细胞提供营养以防止细胞周期停滞；以及使用抗衰老治疗去除老化体细胞。还揭示了去除斑块后内源神经干细胞的增殖，用于治疗阿尔茨海默病。
• Methods and compositions for restoring homeostatic capacity of a subject
  申请人：Palo Alto Investors

  公开号：US10835134B2

  公开（公告）日：2020-11-17

  Methods of restoring homeostatic capacity of a subject are provided. Aspects of the invention further include compositions, systems and devices for practicing the methods. The methods and compositions described herein find use in a variety of applications. Aspects of certain embodiments of the methods include modulating a subject's autonomic nervous system in a manner sufficient to restore the homeostatic capacity of the subject. Aspects of other embodiments of the invention include administering to the subject an amount of an apoptosis modulator effective to at least partially restore homeostatic function of the neuroendocrine system of the subject.

  本发明提供了恢复受试者体内平衡能力的方法。本发明的各个方面还包括用于实施这些方法的组合物、系统和设备。本文所述的方法和组合物可用于多种应用。本发明方法的某些实施方案包括以足以恢复受试者平衡能力的方式调节受试者的自律神经系统。本发明其他实施方案的方面包括向受试者施用一定量的细胞凋亡调节剂，其有效量至少可部分恢复受试者神经内分泌系统的平衡功能。
• Compositions for reducing mitochondrial dysfunction
  申请人：Dischler Louis

  公开号：US11090320B2

  公开（公告）日：2021-08-17

  Disclosed are methods and compositions for reducing the epigenetic age of organisms, especially that of adult humans, which provide for proliferating endogenous stem cells, removing aberrant epigenetic marks from chromosomes and mitochondrial DNA, and replacement of senescent cells.

  所公开的是降低生物体（尤其是成年人类）表观遗传年龄的方法和组合物，可用于增殖内源性干细胞、去除染色体和线粒体 DNA 上的异常表观遗传标记以及替换衰老细胞。
• Methods and compositions for rapidly decreasing epigenetic age and restoration of more youthful function
  申请人：Dischler Louis

  公开号：US11317646B2

  公开（公告）日：2022-05-03

  Disclosed are methods and compositions of reducing the epigenetic age of mammalian organism, especially an adult human of geriatric age. The methods provide for the proliferation of endogenous stem cells using mitochondrial fusion and a UCP2 blocker or other stimulants; supplying stem cells with nutrition to prevent cell cycle arrest; and removal of senescent somatic cells using senolytic treatments. The proliferation of endogenous neural stem cells after plaque removal for the treatment of Alzheimer's is also disclosed.

  本发明公开了降低哺乳动物机体表观遗传年龄的方法和组合物，特别是老年成人。这些方法利用线粒体融合和 UCP2 阻断剂或其他刺激剂使内源性干细胞增殖；为干细胞提供营养以防止细胞周期停滞；以及利用衰老治疗去除衰老的体细胞。此外，还披露了内源性神经干细胞在去除斑块治疗阿尔茨海默氏症后的增殖情况。
• Methods for reducing mitochondrial dysfunction
  申请人：Dischler Louis

  公开号：US11324764B2

  公开（公告）日：2022-05-10

  Disclosed are methods and compositions for reducing the epigenetic age of organisms, especially that of adult humans, which provide for proliferating endogenous stem cells, removing aberrant epigenetic marks from chromosomes and mitochondrial DNA, and replacement of senescent cells.

  所公开的是降低生物体（尤其是成年人类）表观遗传年龄的方法和组合物，可用于增殖内源性干细胞、去除染色体和线粒体 DNA 上的异常表观遗传标记以及替换衰老细胞。