N-(3-(pyrrolidin-2-yl)phenyl)acetamide | 1270491-32-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: N-(3-(pyrrolidin-2-yl)phenyl)acetamide
• 英文别名: N-[3-(pyrrolidin-2-yl)phenyl]acetamide；N-(3-pyrrolidin-2-ylphenyl)acetamide
• CAS: 1270491-32-1
• 化学式: C₁₂H₁₆N₂O
• 分子量: 204.272
• InChiKey: RPFLVYPXWSFWID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(3-(pyrrolidin-2-yl)phenyl)acetamide 生成 N-[3-[(2S)-pyrrolidin-2-yl]phenyl]acetamide 、 N-[3-[(2R)-pyrrolidin-2-yl]phenyl]acetamide
  参考文献：
  名称：

  WO2006/76246

  摘要：

  公开号：

文献信息

• Method of producing p-Hydroxyphenylalkanols
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20030195379A1

  公开（公告）日：2003-10-16

  Disclosed are a method of producing p-hydroxyphenylalkanol of formula.(I): 1 wherein R 1 and R 2 independently represent hydrogen, an alkyl or a phenyl which may be substituted with an alkyl, or the like, R 3 , R 4 , R 5 , R 6 and R 7 independently represent hydrogen, an alkyl or the like and n denotes an integer from 0 to 7, the method being characterized in that a phenol compound of formula (II): 2 wherein R 1 and R 2 respectively represent the aforementioned meaning, is reactedwith an unsaturated alcohol of formula (III): R 3 R 4 C=C(R 5 )-C(R 6 )(R 7 )-(CH 2 ) n -OH (III) wherein R 3 , R 4 , R 5 , R 6 , R 7 and n respectively represent the same as defined above, in the presence of (A) at least one compound selected from the group consisting of alkali metals, alkali metal compounds, alkaline earth metals and alkaline earth metal compounds and (B) at least one compound selected from the group consisting of transition metals and transition metal compounds, and the like.

  公开了一种制备式（I）的对羟基苯基醇的方法，其中R1和R2分别独立表示氢、烷基或苯基，可以用烷基或类似物取代，R3、R4、R5、R6和R7分别独立表示氢、烷基或类似物，n表示0至7的整数。该方法的特征在于，在（A）碱金属、碱金属化合物、碱土金属和碱土金属化合物组成的群体中选择至少一种化合物，以及在（B）过渡金属和过渡金属化合物组成的群体中选择至少一种化合物的存在下，将式（II）的酚化合物与式（III）的不饱和醇反应：R3R4C=C(R5)-C(R6)(R7)-(CH2)n-OH（III），其中R3、R4、R5、R6、R7和n分别表示上述定义的相同物。
• Phenylglycinamide derivatives useful as anticoagulants
  申请人：Zhang Xiaojun

  公开号：US20060166997A1

  公开（公告）日：2006-07-27

  The present invention relates generally to phenylglycinamide derivatives that inhibit serine proteases. In particular it is directed to novel phenylglycinamide derivatives, and analogues thereof, which are useful as selective inhibitors of serine protease enzymes of the coagulation cascade; for example thrombin, factor VIIa, factor Xa, factor XIa, factor IXa, and/or plasma kallikrein. In particular, it relates to compounds that are factor VIIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of using the same.

  本发明一般涉及抑制丝氨酸蛋白酶的苯基甘氨酰衍生物。具体而言，本发明涉及新型苯基甘氨酰衍生物及其类似物，其可用作凝血级联反应的丝氨酸蛋白酶酶的选择性抑制剂；例如凝血酶、第VIIa因子、第Xa因子、第XIa因子、第IXa因子和/或血浆激肽。特别是，它涉及到的化合物是第VIIa因子的抑制剂。本发明还涉及包含这些化合物的制药组合物及其使用方法。
• Method of producing p-hydroxyphenylalkanols
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP1348686A1

  公开（公告）日：2003-10-01

  Disclosed is a method of producing a p-hydroxyphenylalkanol of formula (I): wherein R1 and R2 independently represent hydrogen, alkyl, phenyl which may be substituted with alkyl, or the like, R3, R4, R5, R6 and R7 independently represent hydrogen or alkyl and n denotes an integer from 0 to 7, which method comprises reacting a phenol compound of formula (II): wherein R1 and R2 are as defined above, with an unsaturated alcohol of formula (III):         R3R4C=C(R5)-C(R6)(R7)-(CH2)n-OH     (III) wherein R3, R4, R5, R6, R7 and n are as defined above,    in the presence of (A) at least one member selected from the group consisting of alkali metals, alkali-metal compounds, alkaline earth metals and alkaline earth metal compounds and (B) at least one member selected from the group consisting of transition metals and transition metal compounds, or    in the presence of (a) an alkali metal or an alkali metal compound, and (b) an alkaline earth metal or an alkaline earth metal compound.

  本发明公开了一种生产式(I)的对羟基苯烷醇的方法： 其中 R1 和 R2 独立地代表氢、烷基、可被烷基取代的苯基或类似物，R3、R4、R5、R6 和 R7 独立地代表氢或烷基，n 表示 0 至 7 的整数，该方法包括使式（II）的苯酚化合物与式（III）的不饱和醇反应： 其中 R1 和 R2 如上定义，与式 (III) 的不饱和醇反应： R3R4C=C(R5)-C(R6)(R7)-(CH2)n-OH (III) 其中 R3、R4、R5、R6、R7 和 n 如上定义、 (A)至少一种选自碱金属、碱金属化合物、碱土金属和碱土金属化合物组成的组，和 (B)至少一种选自过渡金属和过渡金属化合物组成的组，或 (a) 碱金属或碱金属化合物，和 (b) 碱土金属或碱土金属化合物。
• PHENYLGLYCINAMIDE DERIVATIVES USEFUL AS ANTICOAGULANTS
  申请人：Bristol-Myers Squibb Company

  公开号：EP1856096B1

  公开（公告）日：2010-09-01
• US6717020B2
  申请人：——

  公开号：US6717020B2

  公开（公告）日：2004-04-06